E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23132
Abstract: Oligodendrocyte progenitor cells (OPCs) are present throughout the adult brain and spinal cord and can replace oligodendrocytes lost to injury, aging, or disease. Their differentiation, however, is inhibited by myelin debris, making clearance of this… read more here.
Keywords: synthetic tlr4; cord; myelin debris; tlr4 agonist ... See more keywords
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.
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DOI: 10.1021/acsnano.2c07798
Abstract: Timely clearance of myelin debris is the premise of neuroinflammation termination and tissue regeneration in multiple sclerosis (MS). Microglia are the main scavengers of myelin debris in MS lesions, but its phagocytic capability is limited… read more here.
Keywords: experimental autoimmune; autoimmune encephalomyelitis; myelin debris; clearance microglia ... See more keywords
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
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DOI: 10.1038/s41593-018-0324-9
Abstract: The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal… read more here.
Keywords: myelin debris; neural injury; macrophage; endothelial cells ... See more keywords