Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05420-0
Abstract: In patients with Charcot–Marie–Tooth disease 1A (CMT1A), peripheral nerves display aberrant myelination during postnatal development, followed by slowly progressive demyelination and axonal loss during adult life. Here, we show that myelinating Schwann cells in a… read more here.
Keywords: cmt1a; myelin lipid; model cmt1a; potential therapeutic ... See more keywords
Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurotrauma"
DOI: 10.1089/neu.2018.5783
Abstract: Myelin-laden macrophages (mye-MΦ), resulting primarily from internalization of myelin debris by infiltrating bone marrow-derived macrophages in spinal cord injury (SCI), trigger inflammatory responses that largely contribute to secondary injury. Adiponectin, which is secreted from adipose… read more here.
Keywords: lipid accumulation; adiporon; myelin lipid; adiponectin ... See more keywords
Myelin lipid deficiency: a new key driver of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.343893
Abstract: Lipids play essential biological functions that include acting as components of biological membranes, energy storage, signaling, nutrients, transporters, enzyme activators, among others. Compared with the multiple research methods to assess DNA, RNA, and protein content,… read more here.
Keywords: myelin lipid; key driver; driver alzheimer; deficiency new ... See more keywords