Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23827
Abstract: Myelin loss in the brain is a common occurrence in traumatic brain injury (TBI) that results from impact-induced acceleration forces to the head. Fast and abrupt head motions, either resulting from violent blows and/or jolts,… read more here.
Keywords: mechanical stretch; loss oligodendrocytes; protein loss; myelin protein ... See more keywords
The Role of Peripheral Myelin Protein 2 in Remyelination
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0494-0
Abstract: The protein component of the myelin layer is essential for all aspects of peripheral nerves, and its deficiency can lead to structural and functional impairment. The presence of peripheral myelin protein 2 (P2, PMP2, FABP8,… read more here.
Keywords: protein; remyelination; peripheral myelin; myelin protein ... See more keywords
Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.161
Abstract: Myelin protein zero-like protein 1 (MPZL1) is a member of the immunoglobulin superfamily, and is also a receptor of concanavalin A (ConA). MPZL1 is upregulated in hepatocellular carcinoma (HCC) and accelerates migration of HCC cells.… read more here.
Keywords: protein; zero like; like protein; extracellular domain ... See more keywords
Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.17.476643
Abstract: Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here… read more here.
Keywords: divergence myelin; mouse; conservation divergence; transcriptome profiles ... See more keywords
Genotype–phenotype correlation in French patients with myelin protein zero gene‐related inherited neuropathy
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neurology"
DOI: 10.1111/ene.14948
Abstract: Preparations for clinical trials of unfolded protein response (UPR) inhibitors (such as Sephin1) that target the upregulated UPR in patients with Charcot–Marie–Tooth disease (CMT) carrying MPZ mutations are currently underway. The inclusion criteria for these… read more here.
Keywords: genotype phenotype; phenotype correlation; myelin protein; french patients ... See more keywords
Colocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030456
Abstract: Myelination of the peripheral nervous system requires Schwann cells (SC) differentiation into the myelinating phenotype. The peripheral myelin protein-22 (PMP22) is an integral membrane glycoprotein, expressed in SC. It was initially described as a growth… read more here.
Keywords: trj mice; myelin protein; pmp22; trj ... See more keywords
Peripheral Myelin Protein 22 Gene Mutations in Charcot-Marie-Tooth Disease Type 1E Patients
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13071219
Abstract: Duplication and deletion of the peripheral myelin protein 22 (PMP22) gene cause Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP), respectively, while point mutations or small insertions and deletions… read more here.
Keywords: gene; charcot marie; type; marie tooth ... See more keywords