Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
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DOI: 10.1038/s41598-020-61928-w
Abstract: Therapeutic success of B cell-targeting approaches in multiple sclerosis (MS) has intensified research into the pathogenic and regulatory roles these cells play in demyelinating disease. Dissecting the function of B cells in the MS mouse… read more here.
Keywords: protein; cell dependent; model; multiple sclerosis ... See more keywords
Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuropathology and Experimental Neurology"
DOI: 10.1093/jnen/nlz058
Abstract: Abstract Using a panel of monoclonal antibodies (mAbs) to myelin proteolipid protein (PLP) peptides, we found that in addition to CNS myelin, mAbs to external face but not cytoplasmic face epitopes immunostained neurons in immature… read more here.
Keywords: monoclonal antibodies; proteolipid protein; differentiation; cell surface ... See more keywords