Microglia: origins, homeostasis, and roles in myelin repair
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.10.001
Abstract: Microglia are the resident macrophages of the central nervous system (CNS), implicated in developmental processes, homeostasis, and responses to injury. Derived from the yolk sac during development, microglia self-renew, self-regulate their numbers during homeostatic conditions,… read more here.
Keywords: homeostasis; myelin repair; homeostasis roles; microglia origins ... See more keywords
miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.03.001
Abstract: A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however, their functions in myelin regeneration remained elusive. Through developmentally regulated targeted mutagenesis, we demonstrate that… read more here.
Keywords: myelin repair; myelination; cns; mir 338 ... See more keywords
Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.258
Abstract: Removal of chondroitin sulfate proteoglycans (CSPGs) with chondroitinase ABC I (ChABC) facilitates axonal plasticity, axonal regeneration and remyelination, following injury to the central nervous system (CNS). However, the ChABC rapidly undergoes thermal inactivity and needs… read more here.
Keywords: psi; myelin repair; chabc psi; porous silicon ... See more keywords
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23735-3
Abstract: The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and… read more here.
Keywords: tet1; myelin repair; dna hydroxymethylation;
Emerging myelin repair agents in preclinical and early clinical development for the treatment of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1762567
Abstract: ABSTRACT Introduction Remyelination is a highly effective regenerative process that can restore axon function, prevent axonal loss, and reverse clinical deficits after demyelination. Hence, the promotion of remyelination is a logical goal in patients with… read more here.
Keywords: myelin repair; remyelination; clinical development; multiple sclerosis ... See more keywords
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178622
Abstract: The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple… read more here.
Keywords: demyelination; myelin repair; acid sphingomyelinase; acute chronic ... See more keywords
Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2202040
Abstract: BACKGROUND Multiple sclerosis (MS) is an autoimmune disease for which bone marrow mesenchymal stem cells (BM-MSCs) have become one of the most promising tools for treatment. Cuprizone(CPZ) induces demyelination in the central nervous system and… read more here.
Keywords: cell treated; group; myelin repair; chronic demyelination ... See more keywords
Can Enhancing Neuronal Activity Improve Myelin Repair in Multiple Sclerosis?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.645240
Abstract: Enhanced neuronal activity in the healthy brain can induce de novo myelination and behavioral changes. As neuronal activity can be achieved using non-invasive measures, it may be of interest to utilize the innate ability of… read more here.
Keywords: neuronal activity; myelin repair; enhancing neuronal; multiple sclerosis ... See more keywords
Brain region dependent molecular signatures and myelin repair following chronic demyelination
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1169786
Abstract: Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions. Remyelination is considered an axonal protection strategy and may… read more here.
Keywords: remyelination; brain; myelin repair; chronic demyelination ... See more keywords