Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
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DOI: 10.1002/bit.26838
Abstract: Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated strategies to… read more here.
Keywords: myelination; regenerating axons; myelination regenerating; cord injury ... See more keywords
Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain
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DOI: 10.1002/dneu.22518
Abstract: The concept of adaptive myelination—myelin plasticity regulated by activity—is an important advance for the field. What signals set up the adaptable pattern in the first place? Here we review work that demonstrates an intrinsic pathway… read more here.
Keywords: smart wiring; adaptive myelination; myelination; myelination sequential ... See more keywords
Sex differences in myelination of the zebra finch vocal control system emerge relatively late in development
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DOI: 10.1002/dneu.22900
Abstract: The role of myelination in the development of motor control is widely known, but its role in the development of cognitive abilities is less understood. Here, we examined sex differences in the development of myelination… read more here.
Keywords: myelination; development; vocal control; sex differences ... See more keywords
Pals1a and aPKCλ are not essential for Schwann cell migration, division or myelination in zebrafish
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DOI: 10.1002/dvdy.547
Abstract: Schwann cells (SCs) are specialized glial cells of the peripheral nervous system that produce myelin and promote fast action potential propagation. In order to myelinate, SCs engage in a series of events that include migration… read more here.
Keywords: myelination; pals1a apkc; migration division; schwann ... See more keywords
The TAM receptor Tyro3 regulates myelination in the central nervous system
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DOI: 10.1002/glia.23113
Abstract: Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction of electrical impulses by axons, as well as providing trophic support to neurons. Within the central nervous system, the oligodendrocyte is the… read more here.
Keywords: gas6; nervous system; central nervous; myelination ... See more keywords
Schwann cell‐specific deletion of the endosomal PI 3‐kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2‐ErbB3 tyrosine kinase signaling
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DOI: 10.1002/glia.23173
Abstract: The PI 3‐kinase Vps34 (Pik3c3) synthesizes phosphatidylinositol 3‐phosphate (PI3P), a lipid critical for both endosomal membrane traffic and macroautophagy. Human genetics have implicated PI3P dysregulation, and endosomal trafficking in general, as a recurring cause of… read more here.
Keywords: vps34; schwann cell; kinase; myelination ... See more keywords
Ephrin‐A1‐EphA4 signaling negatively regulates myelination in the central nervous system
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DOI: 10.1002/glia.23293
Abstract: During development of the central nervous system not all axons are myelinated, and axons may have distinct myelination patterns. Furthermore, the number of myelin sheaths formed by each oligodendrocyte is highly variable. However, our current… read more here.
Keywords: epha4; nervous system; central nervous; myelination ... See more keywords
Independent and cooperative roles of the Mek/ERK1/2‐MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood
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DOI: 10.1002/glia.23602
Abstract: Multiple extracellular and intracellular signals regulate the functions of oligodendrocytes as they progress through the complex process of developmental myelination and then maintain a functionally intact myelin sheath throughout adult life, preserving the integrity of… read more here.
Keywords: mek erk1; myelination; pi3k akt; developmental myelination ... See more keywords
Co‐culture of exogenous oligodendrocytes with unmyelinated cerebella: Revisiting ex vivo models and new tools to study myelination
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DOI: 10.1002/glia.24001
Abstract: Common in vitro models used to study the mechanisms regulating myelination rely on co‐cultures of oligodendrocyte precursor cells (OPCs) and neurons. In such models, myelination occurs in an environment that does not fully reflect cell–cell… read more here.
Keywords: unmyelinated cerebella; vivo; microscopy; myelination ... See more keywords
CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5
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DOI: 10.1002/glia.24003
Abstract: It is well recognized that astrocytes can produce factors known to affect the myelination process. One such factor, brain‐derived neurotrophic factor (BDNF), can enhance the differentiation of oligodendrocyte lineage cells following a demyelinating lesion. Our… read more here.
Keywords: myelin proteins; metabotropic glutamate; myelination; chpg ... See more keywords
Mek/ERK1/2‐MAPK and PI3K/Akt/mTOR signaling plays both independent and cooperative roles in Schwann cell differentiation, myelination and dysmyelination
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DOI: 10.1002/glia.24049
Abstract: Multiple signals are involved in the regulation of developmental myelination by Schwann cells and in the maintenance of a normal myelin homeostasis throughout adult life, preserving the integrity of the axons in the PNS. Recent… read more here.
Keywords: erk1 mapk; mek erk1; mtor; myelination ... See more keywords