Inhibitors of Myelination and Remyelination, Bone Morphogenetic Proteins, are Upregulated in Human Neurological Disease
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DOI: 10.1007/s11064-020-02980-w
Abstract: During demyelinating disease such as multiple sclerosis and stroke, myelin is destroyed and along with it, the oligodendrocytes that synthesize the myelin. Thus, recovery is limited due to both interruptions in neuronal transmission as well… read more here.
Keywords: morphogenetic proteins; disease; cns; bone morphogenetic ... See more keywords
Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.
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DOI: 10.1016/j.celrep.2019.09.020
Abstract: Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA expressed by OLs, miR-27a, as… read more here.
Keywords: mir 27a; intrinsic mir; remyelination; oligodendrocyte intrinsic ... See more keywords
Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1922089117
Abstract: Significance Remyelination is a natural regenerative process driven by oligodendrocytes that occurs following myelin damage. Understanding this process holds therapeutic value for demyelinating diseases such as multiple sclerosis, in which remyelination can fail. CCN3 is… read more here.
Keywords: remyelination; myelination; cns; expression ... See more keywords