Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26828
Abstract: Atypical chronic myeloid leukemia (aCML) and myelodysplastic/myeloproliferative (MDS/MPN) neoplasms, not otherwise specified (NOS), are MDS/MPN overlap neoplasms characterized by leukocytosis, in the absence of monocytosis and eosinophilia, with read more here.
Keywords: myeloid leukemia; chronic myeloid; atypical chronic; myelodysplastic myeloproliferative ... See more keywords
1004 - HOW DO SRSF2P95H MUTATIONS LEAD TO MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME (MDS/MPN)?
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.242
Abstract: SRSF2 P95 mutations are prevalent in myelodysplastic (MDS) and myelodysplastic/myeloproliferative (MDS/MPN) syndromes. They occur early in the course of the disease, are positively selected during disease progression and are associated with poor outcomes. Understanding how… read more here.
Keywords: mds; myelodysplastic myeloproliferative; mds mpn; srsf2p95h ... See more keywords
3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.12.004
Abstract: 3q26.2/EVI1 rearrangements resulting in EVI1 overexpression play an important role in leukemogenesis and are associated with treatment resistance and a poorer prognosis in patients with acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia and BCR-ABL… read more here.
Keywords: 3q26 evi1; prognosis; myelodysplastic myeloproliferative; evi1 rearrangements ... See more keywords
Turning the tide in myelodysplastic/myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2017.40
Abstract: Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive myeloid malignancies recognized as a distinct category owing to their unique combination of dysplastic and proliferative features. Although current classification schemes still emphasize morphology and exclusionary criteria, disease-defining somatic… read more here.
Keywords: tide myelodysplastic; myeloproliferative neoplasms; myelodysplastic myeloproliferative; turning tide ... See more keywords
Myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T): Mayo-Moffitt collaborative study of 158 patients
Sign Up to like & getrecommendations! Published in 2022 at "Blood Cancer Journal"
DOI: 10.1038/s41408-022-00622-8
Abstract: The current World Health Organization (WHO) classification of myeloid malignancies includes myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) as a distinct entity. Previous literature on predictors of survival was based on the provisional category… read more here.
Keywords: thrombocytosis; mds mpn; myeloproliferative neoplasms; myelodysplastic myeloproliferative ... See more keywords
Genomics of myelodysplastic/myeloproliferative neoplasm.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2023.04.005
Abstract: Myelodysplastic/ Myeloproliferative neoplasms (MDS/MPN) demonstrate overlapping pathologic and molecular features of myelodysplastic (MDS) and myeloproliferative (MPN) neoplasms. Diagnosis is difficult based on morphology alone, requiring exclusion of various non-neoplastic causes for CBC abnormalities and morphologic… read more here.
Keywords: genomics myelodysplastic; classification; myeloproliferative neoplasm; mds mpn ... See more keywords
Pegylated Interferon in Myelodysplastic/Myeloproliferative Syndrome with Ringsideroblasts and Thrombocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129077
Abstract: Background:In 2016 WHO recognized the provisional entity refractory anemia with ring sideroblasts and thrombocytosisas a distinct entity and renamed it myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T). The disease presents hallmarks of both myelodysplastic… read more here.
Keywords: pegylated interferon; thrombocytosis; treatment; myelodysplastic myeloproliferative ... See more keywords
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004229
Abstract: Over 90% of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) harbor somatic mutations in myeloid-related genes, but still, current diagnostic criteria do not include molecular data. We performed genome-wide sequencing techniques to characterize the mutational landscape of a large… read more here.
Keywords: clonal architecture; mpn; myelodysplastic myeloproliferative; myeloproliferative neoplasms ... See more keywords