Results of second salvage therapy in 673 adults with acute myelogenous leukemia treated at a single institution since 2000
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DOI: 10.1002/cncr.31370
Abstract: The prognosis is poor for patients who have relapsed‐refractory acute myelogenous leukemia (AML). Most published reports analyzed results from therapies in first‐salvage AML or in studies that were conducted before 2000. Several novel agents and… read more here.
Keywords: since 2000; results second; myelogenous leukemia; second salvage ... See more keywords
Medicare and patient spending among beneficiaries diagnosed with chronic myelogenous leukemia
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DOI: 10.1002/cncr.32137
Abstract: The authors examined Medicare spending and patient spending in older patients with chronic myelogenous leukemia (CML) over the first 5 years from the time of CML diagnosis in the tyrosine kinase inhibitor (TKI) era. read more here.
Keywords: patient spending; medicare patient; chronic myelogenous; myelogenous leukemia ... See more keywords
Late mortality after bone marrow transplant for chronic myelogenous leukemia in the context of prior tyrosine kinase inhibitor exposure: A Blood or Marrow Transplant Survivor Study (BMTSS) report
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DOI: 10.1002/cncr.32443
Abstract: Late mortality was investigated in patients with chronic myelogenous leukemia (CML) who underwent blood or bone marrow transplant (BMT) with or without prior tyrosine kinase inhibitor (TKI) therapy. read more here.
Keywords: late mortality; chronic myelogenous; myelogenous leukemia; marrow transplant ... See more keywords
BL‐8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open‐label safety and efficacy phase 2a study
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DOI: 10.1002/cncr.33338
Abstract: CXCR4 mediates the retention and survival of acute myelogenous leukemia blasts in bone marrow and contributes to their resistance to chemotherapy. The authors evaluated a combination of the high‐affinity CXCR4 antagonist BL‐8040 with high‐dose cytarabine… read more here.
Keywords: relapsed refractory; cxcr4 antagonist; myelogenous leukemia; phase study ... See more keywords
T‐cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR‐ABL transcripts and t(10;11)(q11;p15)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23241
Abstract: Blast transformation of chronic myelogenous leukemia (CML) to T lymphoblastic lymphoma/acute lymphoblastic leukemia (T‐LBL/ALL) is rare, and the molecular mechanism is still unclear. read more here.
Keywords: cell blast; blast crisis; chronic myelogenous; myelogenous leukemia ... See more keywords
Myelolipoma/extramedullary hematopoiesis within adrenal cortical adenoma increased in size during chronic myelogenous leukemia treatment
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Hematology"
DOI: 10.1007/s00277-022-04768-0
Abstract: A 55-year-old man presented to our hospital because of leukocytosis in October 2020. He had a history of hypertension and suffered from recurrent pancreatitis since the previous year. Laboratory findings on admission were as follows:… read more here.
Keywords: size; myelogenous leukemia; mass; hematopoiesis ... See more keywords
A Multi-disciplinary Approach to Managing Chronic Myelogenous Leukemia Patients on Oral Anticancer Therapy at a Large Academic Medical Center
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DOI: 10.1007/s11899-021-00659-9
Abstract: Since the discovery of imatinib, an oral breakpoint cluster region—Abelson murine leukemia tyrosine kinase inhibitor, chronic myelogenous leukemia transformed from a hematologic malignancy primarily treated with intravenous chemotherapy to a disease almost solely managed with… read more here.
Keywords: oral anticancer; large academic; chronic myelogenous; myelogenous leukemia ... See more keywords
Cutaneous polyarteritis nodosa presenting as a paraneoplastic phenomenon in chronic myelogenous leukemia
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DOI: 10.1016/j.jdcr.2021.03.039
Abstract: c-ANCA: cytoplasmic antineutrophil antibodies CML: chronic myelogenous leukemia cPAN: cutaneous polyarteritis nodosa PAN: polyarteritis nodosa INTRODUCTION There is a well-established relationship between vasculitides andmalignancy. Themost common type of cutaneous vasculitis associated with both hematologic and… read more here.
Keywords: polyarteritis nodosa; polyarteritis; chronic myelogenous; myelogenous leukemia ... See more keywords
DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.
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DOI: 10.1016/j.leukres.2017.03.014
Abstract: INTRODUCTION Extensive studies on SHP-1 protein and SHP-1 mRNA revealed that the diminishment or abolishment of the expression of SHP-1 in leukemias/lymphomas was due to aberrant promoter methylation. Thus far, the mechanism of epigenetic silencing… read more here.
Keywords: methylation; silencing shp; shp gene; chronic myelogenous ... See more keywords
Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen.
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DOI: 10.1016/j.yexcr.2019.05.021
Abstract: Acute myelogenous leukemia (AML) is a hematological malignancy marked by the accumulation of large numbers of immature myeloblasts in bone marrow. The overall prognosis in AML is poor; hence, there is a pressing need to… read more here.
Keywords: drug regimen; myelogenous leukemia; pivotal role; ceramide tamoxifen ... See more keywords
A STEMI MIMIC: MYOCARDIAL INVASION BY THE ACUTE MYELOGENOUS LEUKEMIA
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DOI: 10.1016/s0735-1097(20)33078-3
Abstract: Secondary cardiac cancer commonly occurs via metastatic spread into pericardium and myocardium from primary neoplastic process. ST segment elevation can mimic acute coronary syndrome despite absence of coronary obstruction. A 33-year old male with history… read more here.
Keywords: mimic myocardial; invasion acute; stemi mimic; myelogenous leukemia ... See more keywords