The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+‐LRMDA Axis in Myeloid Cells
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202857
Abstract: The transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system. Here, it is shown that TRPV2 in myeloid cells facilitates… read more here.
Keywords: trpv2; infection; myeloid cells; lrmda ... See more keywords
Arginase‐1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5542
Abstract: Philadelphia‐negative myeloproliferative neoplasms (MPN) are clonal myeloid proliferative disorders characterized by sustained systemic inflammation. Despite its renowned importance, the knowledge concerning the inflammatory pathophysiology of these conditions is currently limited to studies on serum cytokines,… read more here.
Keywords: bone marrow; myeloid cells; myeloid; marrow myeloid ... See more keywords
Full spectrum cytometry improves the resolution of highly autofluorescent biological samples: Identification of myeloid cells in regenerating skeletal muscles
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24568
Abstract: Autofluorescence (AF) is an intrinsic characteristic of cells caused by the presence of fluorescent biological compounds within the cell; these can include structural proteins (e.g., collagen and elastin), cellular organelles, and metabolites (e.g., aromatic amino… read more here.
Keywords: myeloid cells; highly autofluorescent; full spectrum; regenerating skeletal ... See more keywords
Comprehensive characterization of myeloid cells during wound healing in healthy and healing‐impaired diabetic mice
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948438
Abstract: Abstract Wound healing involves the concerted action of various lymphoid and in particular myeloid cell populations. To characterize and quantitate different types of myeloid cells and to obtain information on their kinetics during wound healing,… read more here.
Keywords: wound healing; myeloid cells; healing impaired; mice ... See more keywords
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
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DOI: 10.1002/glia.24252
Abstract: The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activated by antibodies targeting the… read more here.
Keywords: trem2; receptor expressed; triggering receptor; myeloid cells ... See more keywords
Mechanisms of HIV‐1 cell‐to‐cell transfer to myeloid cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4mr0322-737r
Abstract: In addition to CD4+ T lymphocytes, cells of the myeloid lineage such as macrophages, dendritic cells (DCs), and osteoclasts (OCs) are emerging as important target cells for HIV‐1, as they likely participate in all steps… read more here.
Keywords: cell; cell cell; myeloid cells; cell transfer ... See more keywords
T cells dominate peripheral inflammation in a cross‐sectional analysis of obesity‐associated diabetes
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DOI: 10.1002/oby.23528
Abstract: Myeloid cells dominate metabolic disease‐associated inflammation (metaflammation) in mouse obesity, but the contributions of myeloid cells to the peripheral inflammation that fuels sequelae of human obesity are untested. This study used unbiased approaches to rank… read more here.
Keywords: inflammation; peripheral inflammation; myeloid cells; dominate peripheral ... See more keywords
Cancer Stem Cells in the Immune Microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9620-6_12
Abstract: Cancer stem cells are a subpopulation of cancer cells responsible for the most demanding and aggressive cancer cell phenotypes: therapy resistance, a self-protective feature of stem cells; distant metastasis, requiring anchorage independence for survival in… read more here.
Keywords: cancer stem; myeloid cells; biology; cancer ... See more keywords
Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-1966-2
Abstract: Immunotherapies emerged as an alternative for cancer treatment, yet their clinical efficacies are still limited, especially in case of solid tumors. Myeloid immune cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), are often hijacked… read more here.
Keywords: myeloid cells; oligonucleotide therapeutics; stat3; cancer ... See more keywords
Regulatory myeloid cells: an underexplored continent in B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2036-5
Abstract: In lymphomas arising from the germinal center, prognostic factors are linked to the myeloid compartment. In particular, high circulating monocyte or myeloid-derived suppressor cell counts are associated with poor prognosis for patients with high-grade B-cell… read more here.
Keywords: regulatory myeloid; cells underexplored; myeloid cells; cell lymphomas ... See more keywords
Preclinical ImmunoPET Imaging of Glioblastoma-Infiltrating Myeloid Cells Using Zirconium-89 Labeled Anti-CD11b Antibody
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01427-1
Abstract: Purpose Glioblastoma is a lethal brain tumor, heavily infiltrated by tumor-associated myeloid cells (TAMCs). TAMCs are emerging as a promising therapeutic target as they suppress anti-tumor immune responses and promote tumor cell growth. Quantifying TAMCs… read more here.
Keywords: myeloid cells; cd11b antibody; cd11b; anti cd11b ... See more keywords