PHF6 mutation is associated with poor outcome in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5173
Abstract: Mutation of plant homeodomain finger protein 6 (PHF6) occurs in approximately 3% of acute myeloid leukaemia (AML) cases. Although it was reported to be associated with poor prognosis, it was not confirmed by other groups.… read more here.
Keywords: acute myeloid; myeloid leukaemia; associated poor; mutation ... See more keywords
The new HFA/ICOS risk assessment tool to identify patients with chronic myeloid leukaemia at high risk of cardiotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13897
Abstract: Tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukaemia (CML) can cause cardiovascular adverse events. So far, the Systematic Coronary Risk Evaluation (SCORE) charts of the European Society of Cardiology (ESC) have been used… read more here.
Keywords: oncology; chronic myeloid; risk; myeloid leukaemia ... See more keywords
Early platelet elevation after complete remission as a prognostic marker of favourable outcomes in favourable‐ and intermediate‐risk acute myeloid leukaemia: A retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24221
Abstract: Platelet (PLT) recovery after chemotherapy is associated with the prognosis of patients with acute myeloid leukaemia (AML). This study aimed to explore the prognostic significance of early high PLT values in patients with de novo… read more here.
Keywords: platelet; acute myeloid; myeloid leukaemia; complete remission ... See more keywords
Epigenetic silencing of E‐cadherin gene induced by lncRNA MALAT‐1 in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24556
Abstract: Epigenetic abnormalities in acute myeloid leukaemia provide us with a target for novel therapeutic strategies. The aim of the study was to verify the epigenetic regulatory mechanism of E‐cadherin gene silencing induced by long non‐coding… read more here.
Keywords: cadherin gene; acute myeloid; epigenetic silencing; myeloid leukaemia ... See more keywords
Cachectic muscle wasting in acute myeloid leukaemia: a sleeping giant with dire clinical consequences
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12880
Abstract: Acute myeloid leukaemia (AML) is a haematological malignancy with poor survival odds, particularly in the older (>65 years) population, in whom it is most prevalent. Treatment consists of induction and consolidation chemotherapy to remit the… read more here.
Keywords: muscle; acute myeloid; muscle wasting; myeloid leukaemia ... See more keywords
A rare cause of respiratory failure in acute myeloid leukaemia patient
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04172-6
Abstract: Dear Editor, A 24-year-old Moroccan woman, from a rural area, presented with a 2-month history of progressive fatigue, dyspnea and abdominal pain. Physical examination was normal. Her past history included diabetes. Laboratory investigations showed a… read more here.
Keywords: myeloid leukaemia; acute myeloid; leukaemia; respiratory failure ... See more keywords
Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia
Sign Up to like & getrecommendations! Published in 2020 at "Current Oncology Reports"
DOI: 10.1007/s11912-020-0885-0
Abstract: Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic… read more here.
Keywords: bone marrow; leukaemia; myeloid leukaemia; acute myeloid ... See more keywords
Four-Dimensional Echocardiographic Evaluation of Left Ventricular Systolic Functions in Patients with Chronic Myeloid Leukaemia Receiving Tyrosine Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-020-09613-2
Abstract: Tyrosine kinase inhibitors (TKIs) are established treatment for haematological malignancies. However, cardiac adverse effects, including the reduction in left ventricular ejection fraction and symptomatic heart failure remain clinical problems. The purpose of this study was… read more here.
Keywords: ventricular systolic; myeloid leukaemia; patients chronic; chronic myeloid ... See more keywords
Targeting ADP-ribosylation by PARP inhibitors in acute myeloid leukaemia and related disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.04.019
Abstract: Acute myeloid leukaemia (AML) is a highly heterogeneous disease characterized by uncontrolled proliferation, block in myeloid differentiation and recurrent genetic abnormalities. In the search of new effective therapies, identification of synthetic lethal partners of AML… read more here.
Keywords: adp ribosylation; targeting adp; myeloid leukaemia; ribosylation parp ... See more keywords
Alliance of galectin-3 and CD74 biochemical networks as a crucial component of survival machinery operated by human acute myeloid leukaemia cells
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.05.051
Abstract: Acute myeloid leukaemia (AML) is a severe systemic malignancy this enzyme (the enzyme has three subunits – structural (A), regulatory originated from self-renewing transformed immature myeloid precursors. AML can often be a fatal disease since… read more here.
Keywords: biochemical networks; machinery; myeloid leukaemia; acute myeloid ... See more keywords
Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.04.038
Abstract: PURPOSE The current standard-of-care for front-line therapy for acute myeloid leukaemia (AML) results in short-term and long-term toxicity, but still approximately 40% of children relapse. Therefore, there is a major need to accelerate the evaluation… read more here.
Keywords: strategy forum; paediatric strategy; drug; myeloid leukaemia ... See more keywords