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Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.15991
Abstract: Key Points Question Is there an association between dynamic measurable residual disease, treatment, and outcomes among adults with intermediate-risk acute myeloid leukemia? Findings In this registry-based cohort study that included 549 younger patients (aged 14-60…
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Keywords:
risk acute;
myeloid leukemia;
measurable residual;
residual disease ... See more keywords
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Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.6435
Abstract: Importance Therapy-related myeloid neoplasms are a potentially life-threatening consequence of treatment for autoimmune disease (AID) and an emerging clinical phenomenon. Objective To query the association of cytotoxic, anti-inflammatory, and immunomodulating agents to treat patients with…
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Keywords:
myeloid neoplasm;
myeloid leukemia;
autoimmune disease;
association ... See more keywords
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Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12186
Abstract: The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50%…
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Keywords:
cml;
myeloid leukemia;
tpl2;
resistance ... See more keywords
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Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12549
Abstract: Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells (HSPCs). Achieving greater success with therapeutic antibodies requires careful characterization of…
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Keywords:
myeloid leukemia;
monocytic differentiation;
cd300f;
acute myeloid ... See more keywords
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Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12814
Abstract: Acute myeloid leukemia (AML) is the second most common type of leukemia worldwide. It was previously reported that expression of the long noncoding RNA LOC285758 is positively associated with AML cell proliferation, but the underlying…
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Keywords:
loc285758;
myeloid leukemia;
rna loc285758;
acute myeloid ... See more keywords
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Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104823
Abstract: AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of the kinase inhibitor in a Phase III clinical trial. Simultaneously targeting the catalytic and noncatalytic functions…
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Keywords:
protac cocktail;
myeloid leukemia;
acute myeloid;
stem ... See more keywords
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Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105811
Abstract: Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM) microenvironment, which have been widely implicated in pathways that contribute to leukemia growth and resistance. Recent reports showed genotypic and phenotypic alterations in…
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Keywords:
myeloid leukemia;
mesenchymal stromal;
leukemia;
acute myeloid ... See more keywords
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Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24736
Abstract: Aurora kinases are involved in the pathophysiology of several cancers including acute myeloid leukemia (AML). In this phase 1 study, we investigated the safety and efficacy of AMG 900, an orally administered, highly potent, selective,…
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Keywords:
myeloid leukemia;
amg 900;
acute myeloid;
phase study ... See more keywords
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Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24847
Abstract: The aim of this study was to evaluate the efficacy and feasibility of intensified consolidation therapy employing fludarabine and ARA-C in cycle 1 and intermediate-dose ARA-C (IDAC) in cycles 2 through 4, in elderly acute…
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Keywords:
consolidation;
hospitalization;
myeloid leukemia;
efficacy ... See more keywords
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Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.24981
Abstract: dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol. 2012;30(21):2670–2677. [5] Dombret H, Seymour JF, Butrym A, et al. International phase 3 study of azacitidine vs conventional…
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Keywords:
older patients;
myeloid leukemia;
blood;
acute myeloid ... See more keywords
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Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25004
Abstract: Patients with acute myeloid leukemia (AML) in relapse or refractory to induction therapy have a dismal prognosis. Allogeneic hematopoietic stem cell transplantation is the only curative option. In these patients, we aimed to compare the…
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Keywords:
refractory relapsed;
myeloid leukemia;
stem cell;
conditioning regimen ... See more keywords