Association Between Measurable Residual Disease in Patients With Intermediate-Risk Acute Myeloid Leukemia and First Remission, Treatment, and Outcomes
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DOI: 10.1001/jamanetworkopen.2021.15991
Abstract: Key Points Question Is there an association between dynamic measurable residual disease, treatment, and outcomes among adults with intermediate-risk acute myeloid leukemia? Findings In this registry-based cohort study that included 549 younger patients (aged 14-60… read more here.
Keywords: risk acute; myeloid leukemia; measurable residual; residual disease ... See more keywords
Cytarabine Pharmacogenomics and Outcomes Among Children and Young Adults With Acute Myeloid Leukemia
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DOI: 10.1001/jamanetworkopen.2025.16296
Abstract: Key Points Question Is the ara-C pharmacogenomics score (ACS10), a pharmacogenomics score for pediatric patients with acute myeloid leukemia, clinically relevant in adolescent and young adult patients? Findings In this cohort study with 1086 patients,… read more here.
Keywords: pharmacogenomics outcomes; outcomes among; acute myeloid; cytarabine pharmacogenomics ... See more keywords
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia
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DOI: 10.1001/jamaoncol.2016.6435
Abstract: Importance Therapy-related myeloid neoplasms are a potentially life-threatening consequence of treatment for autoimmune disease (AID) and an emerging clinical phenomenon. Objective To query the association of cytotoxic, anti-inflammatory, and immunomodulating agents to treat patients with… read more here.
Keywords: myeloid neoplasm; myeloid leukemia; autoimmune disease; association ... See more keywords
Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia
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DOI: 10.1002/1878-0261.12186
Abstract: The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50%… read more here.
Keywords: cml; myeloid leukemia; tpl2; resistance ... See more keywords
CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation
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DOI: 10.1002/1878-0261.12549
Abstract: Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells (HSPCs). Achieving greater success with therapeutic antibodies requires careful characterization of… read more here.
Keywords: myeloid leukemia; monocytic differentiation; cd300f; acute myeloid ... See more keywords
Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation
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DOI: 10.1002/1878-0261.13790
Abstract: Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. Nevertheless, the overall complexity of the current protocols, as well as the use of specific biomaterials and procedures, limits the wider adoption of… read more here.
Keywords: humanized scaffolds; acute myeloid; engraftment; xenotransplantation ... See more keywords
The long non‐coding RNA LOC285758 promotes invasion of acute myeloid leukemia cells by down‐regulating miR‐204‐5p
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DOI: 10.1002/2211-5463.12814
Abstract: Acute myeloid leukemia (AML) is the second most common type of leukemia worldwide. It was previously reported that expression of the long noncoding RNA LOC285758 is positively associated with AML cell proliferation, but the underlying… read more here.
Keywords: loc285758; myeloid leukemia; rna loc285758; acute myeloid ... See more keywords
Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis
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DOI: 10.1002/2211-5463.70104
Abstract: Acute myeloid leukemia (AML) is a bone marrow malignancy characterized by arrested early‐stage hematopoietic precursor development. Differentiation therapy, which induces terminal differentiation of immature leukemic cells, is less toxic than standard intensive chemotherapy and a… read more here.
Keywords: differentiation; acute myeloid; monocytic differentiation; klf4 dpysl2a ... See more keywords
A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells
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DOI: 10.1002/advs.202104823
Abstract: AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of the kinase inhibitor in a Phase III clinical trial. Simultaneously targeting the catalytic and noncatalytic functions… read more here.
Keywords: protac cocktail; myeloid leukemia; acute myeloid; stem ... See more keywords
Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities
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DOI: 10.1002/advs.202105811
Abstract: Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM) microenvironment, which have been widely implicated in pathways that contribute to leukemia growth and resistance. Recent reports showed genotypic and phenotypic alterations in… read more here.
Keywords: myeloid leukemia; mesenchymal stromal; leukemia; acute myeloid ... See more keywords
Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia
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DOI: 10.1002/advs.202503682
Abstract: Acute Myeloid Leukemia (AML) remains a formidable clinical challenge, predominantly due to the emergence of resistance to existing therapeutic regimens, including BCL‐2 inhibitors like Venetoclax. Here, a novel approach is introduced by engineering BH3 mimetics… read more here.
Keywords: bh3; mcl bcl; acute myeloid; engineering bh3 ... See more keywords