Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.201900577
Abstract: This study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient… read more here.
Keywords: ubiquitin sumo; response; acute myeloid; conjugation ... See more keywords
Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2016.159053
Abstract: Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found that approximately 25% of all… read more here.
Keywords: subset acute; acute myeloid; dehydrogenase 1a1; aldehyde dehydrogenase ... See more keywords
Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis
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DOI: 10.3389/fonc.2022.871590
Abstract: Acute promyelocytic leukemia (APL) accounts for 10–15% of newly diagnosed acute myeloid leukemias (AML) and is typically caused by the fusion of promyelocytic leukemia with retinoic acid receptor α (RARA) gene. The prognosis is excellent,… read more here.
Keywords: acute myeloid; myeloid leukemias; prognosis;
Clonal Architecture and Evolutionary Dynamics in Acute Myeloid Leukemias
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DOI: 10.3390/cancers13194887
Abstract: Simple Summary Acute myeloid leukemias (AML) results from the accumulation of genetic and epigenetic alterations, often in the context of an aging hematopoietic environment. The development of high-throughput sequencing—and more recently, of single-cell technologies—has shed… read more here.
Keywords: leukemic cells; diversity; acute myeloid; genetic epigenetic ... See more keywords