A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.05.001
Abstract: FLT3 fusions are associated with myeloid and lymphoid neoplasms with eosinophilia. We describe a patient presenting with clinicopathologic features of both chronic eosinophilic leukemia, not otherwise specified (CEL, NOS) and systemic mastocytosis (SM). The bone… read more here.
Keywords: neoplasm eosinophilia; flt3 fusion; patient; myeloid lymphoid ... See more keywords
Myeloid/lymphoid neoplasms with eosinophilia and FLT3 rearrangement.
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia research"
DOI: 10.1016/j.leukres.2020.106460
Abstract: Myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement are a unique category in the WHO classification, and include cases with rearrangement of PDGFRA, PDGFRB, FGFR1, and PCM1-JAK2. We report three patients presented with eosinophilia and FLT3… read more here.
Keywords: flt3 rearrangement; lymphoid neoplasms; neoplasms eosinophilia; myeloid lymphoid ... See more keywords
Maintenance 5-azacytidine therapy by MRD monitoring after allogeneic HSCT in myeloid/lymphoid neoplasms with FGFR1 rearrangement
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0436-1
Abstract: Myeloid/lymphoid neoplasms with fibroblast growth factor receptor 1 (FGFR1) rearrangement are rare hematological malignancies. In the 2016 World Health Organization classification, they are listed in myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB,… read more here.
Keywords: fgfr1 rearrangement; lymphoid neoplasms; neoplasms fgfr1; fgfr1 ... See more keywords
Pemigatinib for the treatment of myeloid/lymphoid neoplasms with FGFR1 rearrangement
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2023.2192930
Abstract: ABSTRACT Introduction Myeloid/lymphoid neoplasms with fibroblast growth factor receptor-1 (FGFR1) rearrangements (MLNFGFR1) are rare entities with aggressive features and poor prognosis. Presentation is heterogeneous, ranging from myeloproliferative neoplasms (with or without eosinophilia) to T-cell lymphoma… read more here.
Keywords: lymphoid neoplasms; fgfr1; pemigatinib; treatment ... See more keywords
Complete response of myeloid/lymphoid neoplasms with PDGFRA rearrangement presenting as leukemia/myeloid sarcoma to imatinib monotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000437
Abstract: of myeloperoxidase, CD34, and CD117. Blood tests To the Editor: The presence of FIP-1-like-1-platelet-derived growth factor receptor-a (FIP1L1-PDGFRA, F/P) fusion identified the presence of eosinophilia (3.86 10/L, 49.2% gene accounts for approximately 23% (3%–56%) of… read more here.
Keywords: myeloid; pdgfra; pdgfra rearrangement; myeloid lymphoid ... See more keywords
A TRIP11: FLT3 gene fusion in a patient with myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions: a case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor molecular case studies"
DOI: 10.1101/mcs.a006243
Abstract: Myeloid/lymphoid neoplasms with FLT3 gene fusions have recently been included among myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) in the World Health Organization classification and International Consensus Classification. As this entity remains… read more here.
Keywords: flt3 gene; gene fusions; tyrosine kinase; case ... See more keywords
Hypercobalaminemia in myeloid and lymphoid malignancies
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Haematology"
DOI: 10.1111/ejh.13365
Abstract: Cobalamin, or vitamin B12, is used as a cofactor in a wide range of enzymatic reactions, including the regulation of homocysteine levels and DNA synthesis. Under physiologic circumstances, approximately 80% of the serum cobalamin is… read more here.
Keywords: hypercobalaminemia myeloid; lymphoid malignancies; myeloid lymphoid;
CCDC88C‐FLT3 gene fusion in CD34‐positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17143
Abstract: To the Editor, Rearrangements of PDGFRA, PDGFRB, FGFR1 or JAK2 are established features of myeloid/lymphoid neoplasms with eosinophilia (MLNEo).1 The rearrangement of the fmsrelated tyrosine kinase 3 (FLT3) gene should also be associated with MLNEo,… read more here.
Keywords: flt3 gene; ccdc88c flt3; stem multilineage; haematopoietic stem ... See more keywords
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells
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DOI: 10.18632/oncotarget.22479
Abstract: The fetal liver (FL) is a source of hematopoietic stem and progenitor cells (HSPCs) for transplantation. However, whether FL-HSPCs collected at distinct developmental stages reconstitute similarly or differently in the recipient bone marrow (BM) remains… read more here.
Keywords: recipient bone; hematopoietic stem; myeloid lymphoid; hspcs ... See more keywords
Myeloid/Lymphoid Neoplasm with PDGFRB Rearrangement with t(5;10)(q33;q22) Harboring a Novel Breakpoint of the CCDC6-PDGFRB Fusion Gene
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.3220-19
Abstract: Myeloid/lymphoid neoplasms with PDGFRB rearrangement are a distinct type of myeloid neoplasms that occur in association with rearrangement of PDGFRB at 5q32. The hematological features most often show prominent eosinophilia. We herein report a patient… read more here.
Keywords: pdgfrb fusion; pdgfrb rearrangement; fusion gene; myeloid lymphoid ... See more keywords
Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.187302
Abstract: Myeloid or lymphoid neoplasms associated with eosinophilia (MLN-Eo) are a clinically heterogeneous class of hematologic diseases but present with a limited number of characteristic fusion genes. While the underlying chromosomal aberrations are well characterized, we… read more here.
Keywords: molecular genetic; lymphoid neoplasms; myeloid lymphoid; neoplasms associated ... See more keywords