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   Articles with "myeloid malignancies" as a keyword



Conditioning therapy with N‐acetyl‐L‐cysteine, decitabine and modified BUCY regimen for myeloid malignancies patients prior to allogeneic hematopoietic stem cell transplantation

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recommendations! Published in 2023 at "American Journal of Hematology"

DOI: 10.1002/ajh.26903

Abstract: Conditioning therapy is an essential procedure prior to hematopoietic stem cell transplant (HSCT), imposing a great impact on the outcomes of recipients. We performed a prospective randomized controlled trial to assess the outcome of HSCT… read more here.

Keywords: arm; decitabine; myeloid malignancies; therapy ... See more keywords

Immune‐dysregulation harnessing in myeloid neoplasms

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recommendations! Published in 2024 at "Cancer Medicine"

DOI: 10.1002/cam4.70152

Abstract: Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation… read more here.

Keywords: bone marrow; myeloid malignancies; immune dysregulation;

The role of ASXL1 in hematopoiesis and myeloid malignancies

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recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03084-7

Abstract: Recent high-throughput genome-wide sequencing studies have identified recurrent somatic mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 (ASXL1), is one of the most frequently mutated genes in all subtypes of myeloid malignancies.… read more here.

Keywords: role; myeloid malignancies; asxl1 mutations; hematopoiesis ... See more keywords
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Neutrophilic Dermatoses Associated with Myeloid Malignancies

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recommendations! Published in 2019 at "American Journal of Clinical Dermatology"

DOI: 10.1007/s40257-018-00418-2

Abstract: Neutrophilic dermatoses (ND) are a group of conditions characterized by an aseptic accumulation of polymorphonuclear leukocytes in the skin. Occurrence of ND in association with myeloid malignancies, mainly myelodysplastic syndrome and myelogenous acute leukemia, is… read more here.

Keywords: dermatology; dermatoses associated; neutrophilic dermatoses; associated myeloid ... See more keywords

Decitabine in combination with donor lymphocyte infusions can induce remissions in relapsed myeloid malignancies with higher leukemic burden after allogeneic hematopoietic cell transplantation.

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recommendations! Published in 2018 at "Leukemia research"

DOI: 10.1016/j.leukres.2018.07.005

Abstract: The combination of 5-azacytidine (AZA) with donor lymphocyte infusions (DLIs) can induce remissions in patients with relapsed myeloid malignancies after allo-HCT. As decitabine (DAC) is known to be effective also in AML/MDS with leukocytosis, we… read more here.

Keywords: combination; allo hct; lymphocyte infusions; donor lymphocyte ... See more keywords
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An epitranscriptomic vulnerability in myeloid malignancies

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recommendations! Published in 2017 at "Nature Medicine"

DOI: 10.1038/nm.4435

Abstract: A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML). read more here.

Keywords: medicine; vulnerability myeloid; myeloid malignancies; epitranscriptomic vulnerability ... See more keywords
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Challenges in the introduction of next-generation sequencing (NGS) for diagnostics of myeloid malignancies into clinical routine use

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recommendations! Published in 2018 at "Blood Cancer Journal"

DOI: 10.1038/s41408-018-0148-6

Abstract: Given the vast phenotypic and genetic heterogeneity of acute and chronic myeloid malignancies, hematologists have eagerly awaited the introduction of next-generation sequencing (NGS) into the routine diagnostic armamentarium to enable a more differentiated disease classification,… read more here.

Keywords: sequencing ngs; introduction next; myeloid malignancies; next generation ... See more keywords
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TIM-3 pathway dysregulation and targeting in cancer

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recommendations! Published in 2020 at "Expert Review of Anticancer Therapy"

DOI: 10.1080/14737140.2021.1865814

Abstract: ABSTRACT Introduction Dysfunction of the immune system is a hallmark of cancer. Through increased understanding of the complex interactions between immunity and cancer, immunotherapy has emerged as a treatment modality for different types of cancer.… read more here.

Keywords: pathway dysregulation; treatment; tim; cancer ... See more keywords

Imetelstat in myeloid malignancies: current data and future directions

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recommendations! Published in 2025 at "Expert Review of Anticancer Therapy"

DOI: 10.1080/14737140.2025.2482721

Abstract: ABSTRACT Introduction Telomerase reactivation allows cancer cells to maintain telomere length and evade senescence, making it an appealing therapeutic target. Imetelstat, an antisense oligonucleotide, is the first clinically effective telomerase inhibitor approved by the FDA… read more here.

Keywords: current data; myeloid malignancies; data future; malignancies current ... See more keywords

Treatment of minimal residual disease in myeloid malignancies after allo-HSCT with venetoclax-based regimens in patients ineligible for or failed in the immunotherapy

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recommendations! Published in 2024 at "Hematology"

DOI: 10.1080/16078454.2024.2418653

Abstract: ABSTRACT Background: Relapse was the major cause of treatment failure in patients with myeloid malignancies after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients who still suffer from the disease while cannot be detected by morphological… read more here.

Keywords: myeloid malignancies; venetoclax based; allo hsct; based regimens ... See more keywords

Efficacy of azacitidine in preventing relapse after hematopoietic stem cell transplantation for advanced myeloid malignancies: a systematic review and meta-analysis

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recommendations! Published in 2022 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2022.2073214

Abstract: ABSTRACT Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic malignancies. This… read more here.

Keywords: stem cell; myeloid malignancies; cell transplantation; relapse ... See more keywords