Prospective Identification of Unrelated Donors with Low Inhibitory Donor KIR3DL1 – Recipient HLA-B Interaction Decreases Relapse and Improves Survival after Allogeneic Hematopoietic Cell Transplantation for Myeloid Neoplasia
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DOI: 10.1016/j.bbmt.2019.12.640
Abstract: Retrospective studies indicate that the use of unrelated hematopoietic stem cell donors with Killer Ig-like Receptor (KIR) genotypes resulting in low inhibitory interactions with recipient HLA are associated with lower relapse and higher survival in… read more here.
Keywords: inhibition; hla; transplantation; cell ... See more keywords
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
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DOI: 10.1038/s42003-020-01220-9
Abstract: Loss-of-function TET2 mutations ( TET2 MT ) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2 MT thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA)… read more here.
Keywords: dependent effects; ascorbic acid; tet2; activity ... See more keywords