Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.6435
Abstract: Importance Therapy-related myeloid neoplasms are a potentially life-threatening consequence of treatment for autoimmune disease (AID) and an emerging clinical phenomenon. Objective To query the association of cytotoxic, anti-inflammatory, and immunomodulating agents to treat patients with… read more here.
Keywords: myeloid neoplasm; myeloid leukemia; autoimmune disease; association ... See more keywords
Myeloid neoplasm with PDGFRB rearrangement, presenting as systemic mastocytosis‐chronic eosinophilic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26505
Abstract: IMAGE 1 Peripheral blood film shows circulating mast cells. Both “normal” and “atypical” circulating mast cells were noted. Atypical features included hypogranular spindled cytoplasms and eccentric nuclei (panel A, Wright-Giemsa stain 20 magnification). Panel B… read more here.
Keywords: magnification; myeloid neoplasm; neoplasm pdgfrb; panel ... See more keywords
Myeloid neoplasm with isolated del(5q) and the MPLW515L mutation fulfills the WHO diagnostic criteria for ET
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Hematology"
DOI: 10.1007/s12185-020-02872-3
Abstract: A 70-year-old male was referred to our hospital for marked thrombocytosis without anemia. The patient simultaneously presented with an MPL W515L mutation, one of the major driver mutations in essential thrombocythemia (ET), and deletion of… read more here.
Keywords: isolated del; del mplw515l; neoplasm isolated; myeloid neoplasm ... See more keywords
Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.12.002
Abstract: Myeloid neoplasms are a heterogeneous group of hematologic disorders with divergent patterns of cell differentiation and proliferation, as well as divergent clinical courses. Rare recurrent genetic abnormalities related to this group of cancers are associated… read more here.
Keywords: myeloid neoplasms; myeloid neoplasm; molecular approaches; mecom ... See more keywords
"Reversible" myelodysplastic syndrome or ineffectual clonal haematopoiesis? - add(6p) myeloid neoplasm with a spontaneous cytogenetic remission.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.08.010
Abstract: Cytotoxic chemotherapy has inherent mutagenic potential and alters the bone marrow microenvironment after therapy. In some cases, this potentiates expansion of an aberrant clone and may lead to a therapy-related myeloid neoplasm if the clone… read more here.
Keywords: myeloid neoplasm; clonal haematopoiesis; cytogenetic remission; spontaneous cytogenetic ... See more keywords
Therapy-related myeloid neoplasm in an 18-year-old boy with B-lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2017.11.007
Abstract: BACKGROUND Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Acute myeloid leukemia or myelodysplastic syndrome during the course of ALL is a rare entity. Some of these cases are therapy-related while the others… read more here.
Keywords: therapy related; diagnosis; myeloid neoplasm; lymphoblastic leukemia ... See more keywords
Physician and patient perceptions on randomization of treatment intensity for unfit adults with acute myeloid leukemia and other high-grade myeloid neoplasm
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DOI: 10.1038/s41375-022-01524-1
Abstract: TO THE EDITOR Acute myeloid leukemia (AML) primarily affects older people, and thus many patients are felt to be medically less-than-fit (“unfit”) at the time of initial diagnosis (e.g., because of comorbid illnesses). How best… read more here.
Keywords: myeloid neoplasm; treatment; leukemia; treatment intensity ... See more keywords
The significance of genetic mutations and their prognostic impact on patients with incidental finding of isolated del(20q) in bone marrow without morphologic evidence of a myeloid neoplasm
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DOI: 10.1038/s41408-020-0275-8
Abstract: Patients with a sole del(20q) chromosomal abnormality and without morphologic features of a myeloid neoplasm (MN) have shown variable clinical outcomes. To explore the potential risk stratification markers in this group of patients, we evaluated… read more here.
Keywords: isolated del; without morphologic; myeloid neoplasm; del 20q ... See more keywords
A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm.
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DOI: 10.1093/labmed/lmac010
Abstract: The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic… read more here.
Keywords: myeloid neoplasm; patient myeloid; novel usp25; myeloid ... See more keywords
Clinical Utility of Routine Targeted Next-Generation Sequencing of Peripheral Blood in the Evaluation of Patients with Cytopenias
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DOI: 10.1182/blood-2018-99-117922
Abstract: Background With the increasing accessibility of next-generation sequencing (NGS), many institutions are incorporating routine mutational profiling to assist in the evaluation of patients with a variety of hematologic disorders, including cytopenias. Such testing can be… read more here.
Keywords: hematology; etiology; myeloid neoplasm; peripheral blood ... See more keywords