The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26751
Abstract: A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group… read more here.
Keywords: neoplasms acute; classification; acute leukemias; myeloid neoplasms ... See more keywords
Epidemiologic outlook of therapy‐related myeloid neoplasms and selection of high‐risk patients: A Korean nationwide study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34453
Abstract: Although a considerable proportion of patients with cancer receive chemotherapy (CT) or radiotherapy (RT), only a very few patients eventually develop therapy‐related myeloid neoplasms (t‐MNs). read more here.
Keywords: related myeloid; outlook therapy; myeloid neoplasms; therapy related ... See more keywords
Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.12.002
Abstract: Myeloid neoplasms are a heterogeneous group of hematologic disorders with divergent patterns of cell differentiation and proliferation, as well as divergent clinical courses. Rare recurrent genetic abnormalities related to this group of cancers are associated… read more here.
Keywords: myeloid neoplasms; myeloid neoplasm; molecular approaches; mecom ... See more keywords
Clinical significance of isolated del(7p) in myeloid neoplasms.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.01.016
Abstract: Sole del(7p) is a rare finding in myeloid neoplasms and its clinical significance is largely unknown. Here we report 10 patients with isolated del(7p), 4 had acute myeloid leukemia (AML), 2 myelodysplastic syndromes (MDS), 1… read more here.
Keywords: isolated del; del; myeloid neoplasms; del myeloid ... See more keywords
Diagnostic and therapeutic implications of genetic heterogeneity in myeloid neoplasms uncovered by comprehensive mutational analysis
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2017.09.001
Abstract: While growing use of comprehensive mutational analysis has led to the discovery of innumerable genetic alterations associated with various myeloid neoplasms, the under-recognized phenomenon of genetic heterogeneity within such neoplasms creates a potential for diagnostic… read more here.
Keywords: myeloid neoplasms; genetic heterogeneity; analysis; mutational analysis ... See more keywords
Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2018.06.002
Abstract: Isochromosome 17q (i17q) is a commonly encountered chromosomal abnormality in myeloid neoplasms (MN) where there is a loss of 17p and duplication of 17q – leading to a single copy of 17p and three copies… read more here.
Keywords: myeloid neoplasms; isochromosome 17q; center; abnormality ... See more keywords
Recurrent cyclin D2 mutations in myeloid neoplasms
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.195
Abstract: Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98HOXA9-induced myeloid disease. Leukemia 2015; 29: 2086–2097. 17 Anne M, Sammartino D, Barginear MF, Budman D. Profile of panobinostat and its potential for treatment in… read more here.
Keywords: myeloid neoplasms; mutations myeloid; creative commons; license ... See more keywords
Therapy-related myeloid neoplasms with different latencies: a detailed clinicopathologic analysis
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00958-9
Abstract: Therapy-related myeloid neoplasm (t-MN) arising in patients with prior cytotoxic treatments is considered a distinct entity due to its unfavorable prognosis. Latencies between the initial cytotoxic therapy and the occurrence of t-MNs vary but usually… read more here.
Keywords: myeloid neoplasms; therapy related; mns ordinary; therapy ... See more keywords
Myeloid neoplasms with MYC-positive double minutes: towards recognition as a distinct entity
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DOI: 10.1038/s41408-025-01244-6
Abstract: (dmin) is a rare cytogenetic phenomenon, predominantly associated with acute myeloid leukemia (AML). The acentric chromosomal structures usually represent oncogene ampli fi cation, such as the MYC gene (Fig. 1A), highlighting a pivotal aspect of… read more here.
Keywords: myc positive; dmin; myc; myc dmin ... See more keywords
Clonal evolution in patients developing therapy-related myeloid neoplasms following autologous stem cell transplantation
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DOI: 10.1038/s41409-022-01567-z
Abstract: Clonal hematopoiesis (CH) denotes somatic mutations in genes related to myeloid neoplasms present at any variant allele frequency (VAF). Clonal hematopoiesis is associated with increasing age and with a factor 6 increase in the risk… read more here.
Keywords: therapy related; tmn; related myeloid; myeloid neoplasms ... See more keywords
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms
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DOI: 10.1038/s41467-024-50384-z
Abstract: Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo- and/or radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the mechanisms driving therapy-related leukemogenesis likely vary across different ages. Chemotherapy is… read more here.
Keywords: related myeloid; treatment; therapy; selective pressures ... See more keywords