Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
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DOI: 10.1182/blood.2019003530
Abstract: Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region (HVR) of Ras isoforms underlie differential post-translational modification and subcellular trafficking, potentially resulting in selective vulnerabilities. Specifically, inhibiting the… read more here.
Keywords: palmitoylation; genetic disruption; mice; myeloid transformation ... See more keywords
Increased number of mast cells in the bone marrow of chronic myeloid leukemia may herald the pending myeloid transformation—the mast cell is an indicator of myeloid transformation
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/31783
Abstract: Background: Tumor cells are surrounded by many inflammatory cells, including mast cells (MCs), which can secrete several classic proangiogenic factors, resulting in endothelial cell proliferation and angiogenesis. However, the researches of the number of MC… read more here.
Keywords: myeloid transformation; mast; bone marrow;