TUMOR-DERIVED EXTRACELLULAR VESICLES INHIBIT OSTEOGENESIS AND EXACERBATE MYELOMA BONE DISEASE
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DOI: 10.1016/j.exphem.2019.06.366
Abstract: Background As a hallmark driver of multiple myeloma (MM), MM bone disease (MBD) is unique in thatit is characterized by severely impaired osteoblast activity resulting from blocked osteogenesis in bonemarrow-derived mesenchymal stem cells (BM-MSCs). The… read more here.
Keywords: bone disease; derived extracellular; extracellular vesicles; osteogenesis ... See more keywords
Myeloma-bone marrow adipocyte axis in tumour survival and treatment response.
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DOI: 10.1038/s41416-021-01371-4
Abstract: Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds,… read more here.
Keywords: myeloma bone; survival; myeloma; bone marrow ... See more keywords
Bacterial infections exacerbate myeloma bone disease
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DOI: 10.1186/s12967-021-03187-5
Abstract: Multiple myeloma is characterized by osteolytic lesions caused by reduced bone formation and activated bone resorption. An important feature of myeloma is a failure of bone healing after successful treatment. In this work, clinical studies… read more here.
Keywords: bone; myeloma bone; coli; myeloma ... See more keywords
Hotspots and trends in multiple myeloma bone diseases: A bibliometric visualization analysis
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DOI: 10.3389/fphar.2022.1003228
Abstract: Objective: This study aims to explore the research hotspots and trends of multiple myeloma bone disease in the past 20 years by bibliometric visualization analysis. Methods: With the Web of Science Core Collection database as… read more here.
Keywords: hotspots trends; analysis; myeloma bone; multiple myeloma ... See more keywords
Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease
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DOI: 10.3390/ijms22083840
Abstract: Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It… read more here.
Keywords: myeloma bone; mechanical loading; bone; bone disease ... See more keywords