IL-17A Increases Multiple Myeloma Cell Viability by Positively Regulating Syk Expression
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DOI: 10.1016/j.tranon.2019.04.023
Abstract: PURPOSE: Elevated IL-17 produced by Th17 cells was reported to promote myeloma cell growth and inhibit immune function in multiple myeloma (MM). IL-17A was also reported to promote MM growth through IL-17 receptors and enhance… read more here.
Keywords: viability; cell viability; myeloma cell; expression ... See more keywords
Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma
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DOI: 10.1158/1078-0432.ccr-17-0678
Abstract: Purpose: The search for new drugs that control the continuous relapses of multiple myeloma is still required. Here, we report for the first time the potent antimyeloma activity of amiloride, an old potassium-sparing diuretic approved… read more here.
Keywords: myeloma; diuretic drug; myeloma cell; amiloride old ... See more keywords
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
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DOI: 10.1158/1078-0432.ccr-17-1594
Abstract: Purpose: Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin, and is therefore susceptible to therapies targeting protein homeostasis. We hypothesized that heat shock factor 1 (HSF1) was an attractive therapeutic target… read more here.
Keywords: myeloma; myeloma cell; human myeloma; cell ... See more keywords
Abstract 319: Syntenin regulates multiple myeloma cell survival
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DOI: 10.1158/1538-7445.am2018-319
Abstract: Multiple myeloma is the second most common hematological malignancy with an estimated 30,000 new diagnoses in 2017. Myeloma cells retain numerous characteristics of normal plasma cells including reliance on survival signals in the bone marrow… read more here.
Keywords: myeloma; cell survival; myeloma cell; expression ... See more keywords
Proteasome Subunits Differentially Control Myeloma Cell Viability and Proteasome Inhibitor Sensitivity
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DOI: 10.1158/1541-7786.mcr-19-1026
Abstract: We generated eight multiple myeloma cell lines resistant to bortezomib; five acquired PSMB5 mutations. In 1,500 patients such mutations were rare clinically. To better understand disruption of proteasomes on multiple myeloma viability and drug sensitivity,… read more here.
Keywords: myeloma; multiple myeloma; sensitivity; myeloma cell ... See more keywords
A Role for Syntenin-1 in Multiple Myeloma Cell Survival
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DOI: 10.1182/blood-2018-99-113594
Abstract: Multiple myeloma is the second most common hematological malignancy in the U.S. with an estimated 30,700 new diagnoses in 2018. It is a clonal disease of plasma cells that, despite recent therapeutic advances, remains incurable.… read more here.
Keywords: myeloma; cell survival; myeloma cell; expression ... See more keywords
Myeloma-Specific Oncolytic Adenovirus Induces Significant Tumour Oncolysis In Vitro and In Vivo and Prevents Cell Line Regrowth
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DOI: 10.1182/blood-2018-99-118056
Abstract: Multiple myeloma is a largely incurable disease and despite current therapies achieving good initial responses, patients frequently relapse. Therefore, new approaches are required that not only reduce the tumour load, but also prevent the growth… read more here.
Keywords: myeloma; regrowth; myeloma cell; oncolysis ... See more keywords
PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup
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DOI: 10.1182/blood-2019-124109
Abstract: BACKGROUND: The biological basis for the adverse prognosis of chr1q gain/amplification (1q+) present in ~30% of patients with multiple myeloma (MM) remains ill-defined. The transcription factor (TF) Pre-B-cell leukaemia homeobox 1 (PBX1), encoded on chr1q,… read more here.
Keywords: pbx1; myeloma cell; foxm1; analysis ... See more keywords
Multiple Myeloma Cell Defects Erythropoiesis and Results Anemia Via High Level of CCL3 in Bone Marrow Microenvironment
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DOI: 10.1182/blood-2020-139006
Abstract: Background: Anemia is the most common complication of myeloma, and is associated with worse clinical outcomes including diminished quality of life, and increased risk of morbidity and mortality. Bone marrow (BM) is the main location… read more here.
Keywords: ccl3; anemia; myeloma; myeloma cell ... See more keywords