Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway
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DOI: 10.1002/iub.2684
Abstract: The Akt signaling pathway is an oncogenic cascade activated in the bone marrow microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled proliferation. Abrogation of Akt signaling has been presented as one of… read more here.
Keywords: akt driven; signaling pathway; effect; myeloma cells ... See more keywords
Signal pathways, diseases, and functions associated with the miR‐19a/92a cluster and the use of berberine to modulate the expression of this cluster in multiple myeloma cells
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DOI: 10.1002/jbt.22057
Abstract: Berberine downregulated miR‐19a/92a cluster expression in multiple myeloma (MM) cells. read more here.
Keywords: 19a 92a; cluster; multiple myeloma; myeloma cells ... See more keywords
Morphogens and growth factor signalling in the myeloma bone-lining niche
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03767-0
Abstract: Multiple myeloma is a malignancy caused by the clonal expansion of abnormal plasma cells. Myeloma cells have proven to be incredibly successful at manipulating their microenvironment to promote growth and to evade modern therapies. They… read more here.
Keywords: cell; myeloma; bone; myeloma cells ... See more keywords
Enrichment of circulating myeloma cells by immunomagnetic beads combined with flow cytometry for monitoring minimal residual disease and relapse in patients with multiple myeloma
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DOI: 10.1007/s00277-019-03833-5
Abstract: Difficulty in regularly analyzing marrow myeloma cells (MMCs) and low frequency of circulating myeloma cells (CMCs) in blood presents challenges for monitoring minimal residual disease (MRD) in multiple myeloma (MM). We have developed a set… read more here.
Keywords: imb fcm; circulating myeloma; myeloma cells; myeloma ... See more keywords
Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules
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DOI: 10.1007/s11033-018-4409-z
Abstract: Shelterin complex and its associated molecules are imperative for proper functioning and maintenance of human telomeres. These molecules in association with human telomerase have been found altered in most cancers including multiple myeloma thereby proposed… read more here.
Keywords: combination; myeloma; shelterin complex; complex associated ... See more keywords
Targeting autophagy in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.06.002
Abstract: Autophagy plays an important role in plasma cell ontogeny and in the pathophysiology of multiple myeloma. Autophagy is usually considered a pro-survival mechanism, and cooperates with the ubiquitin proteasome system in maintaining the homeostasis of… read more here.
Keywords: targeting autophagy; autophagy multiple; myeloma; multiple myeloma ... See more keywords
Anti-proliferative activity of CGK012 against multiple myeloma cells via Wnt/β-catenin signaling attenuation.
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DOI: 10.1016/j.leukres.2017.07.001
Abstract: The aberrant activation of Wnt/β-catenin signaling is involved in the development of multiple myeloma; thus, this signaling pathway is a potential target for the development of therapeutics for this malignancy. Here, we performed cell-based chemical… read more here.
Keywords: cgk012; catenin; multiple myeloma; myeloma cells ... See more keywords
Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.12.007
Abstract: Tropolones are naturally occurring seven-membered non-benzenoid aromatic compounds that are of interest due to their cytotoxic properties. MO-OH-Nap is a novel α-substituted tropolone that induces caspase cleavage and upregulates markers associated with the unfolded protein… read more here.
Keywords: unfolded protein; protein response; multiple myeloma; myeloma cells ... See more keywords
Biomimetic mesoporous vectors enabling the efficient inhibition of wild-type isocitrate dehydrogenase in multiple myeloma cells
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DOI: 10.1016/j.micromeso.2021.111320
Abstract: Abstract The discovery of isocitrate dehydrogenases (IDHs) mutations in several malignancies has brought to the approval of drugs targeting IDH1/2 mutants in cancers. More recently it has been suggested that the enzymatic inhibition of IDHs… read more here.
Keywords: drug; multiple myeloma; agi 6780; myeloma cells ... See more keywords
Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy
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DOI: 10.1038/leu.2017.272
Abstract: Adaptive resistance mediated by inhibitory ligands such as PD-L1 has emerged as an important mechanism of malignant cell survival and spurred the development of new agents that disrupt the PD-L1/PD-1 immune checkpoint.1 Analysis of patient… read more here.
Keywords: myeloma; reovirus sensitizes; multiple myeloma; sensitizes multiple ... See more keywords
Dynamic CD138 surface expression regulates switch between myeloma growth and dissemination
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DOI: 10.1038/s41375-019-0519-4
Abstract: The canonical plasma cell marker CD138 (syndecan-1) is highly expressed on the myeloma cell surface, but its functional role in vivo is unclear, as well as the ontogeny of CD138-high and CD138-negative (neg) myeloma cells.… read more here.
Keywords: surface expression; myeloma; cd138 surface; myeloma cells ... See more keywords