Monocyte subsets to differentiate chronic myelomonocytic leukemia from reactive monocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23576
Abstract: Chronic myelomonocytic leukemia (CMML) is characterized by persistent monocytosis and dysplastic features of blood cells. No specific genetic abnormalities are present in CMML, and reactive monocytosis should be excluded. An increase in classical monocytes (MO1)… read more here.
Keywords: monocytosis; monocyte subsets; chronic myelomonocytic; reactive monocytosis ... See more keywords
Recent Updates on Chronic Myelomonocytic Leukemia
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DOI: 10.1007/s11899-018-0475-5
Abstract: Purpose of ReviewThe goal of this review is to provide a practical and comprehensive update on changes in the classification of chronic myelomonocytic leukemia (CMML) and a summary of the most recent developments in our… read more here.
Keywords: recent updates; updates chronic; chronic myelomonocytic; cmml ... See more keywords
Chronic Myelomonocytic Leukemia: 2018 Update to Prognosis and Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-019-00509-9
Abstract: Purpose of ReviewChronic myelomonocytic leukemia (CMML) is a rare and often aggressive myeloid malignancy. Historically, prognostic markers and therapeutic paradigms have been applied from myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPNs). Interest has increased recently… read more here.
Keywords: prognosis; treatment; chronic myelomonocytic; cmml ... See more keywords
Sphenoidal sinogenic extradural empyema associated with juvenile myelomonocytic leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2018.09.016
Abstract: Intracranial empyema is a rare but serious complication of sinusitis in children. Myelodysplastic/myeloproliferative syndromes (MMS), including juvenile myelomonocytic leukemia (JMML), can lead to immunosuppression, thus favouring infections. We report the case of a sphenoid sinogenic… read more here.
Keywords: juvenile myelomonocytic; extradural empyema; empyema; empyema associated ... See more keywords
Peliosis lienalis with atraumatic splenic rupture in a patient with chronic myelomonocytic leukemia: A case report
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2021.02.027
Abstract: Highlights • Peliosis lienalis is a rare pathological entity which may be associated with chronic myelomonocytic leukemia.• Increasing splenomegaly in patients with hematological malignancies should rise suspicion of impending splenic rupture.• Peliosis lienalis may be… read more here.
Keywords: peliosis lienalis; peliosis; splenic rupture; chronic myelomonocytic ... See more keywords
Leukemia cutis in a child with juvenile myelomonocytic leukemia presenting with Sweet syndrome–like lesions and a history of multiple juvenile xanthogranulomas
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DOI: 10.1016/j.jdcr.2020.08.030
Abstract: JMML: juvenile myelomonocytic leukemia JXG: juvenile xanthogranulomas LCH: Langerhans cell histiocytosis INTRODUCTION Juvenile myelomonocytic leukemia (JMML) is a rare leukemia affecting children. It is known to be associated with multiple juvenile xanthogranulomas (JXG) and neurofibromatosis… read more here.
Keywords: juvenile myelomonocytic; juvenile xanthogranulomas; juvenile; leukemia cutis ... See more keywords
Spontaneous splenic rupture – An uncommon complication of chronic myelomonocytic leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2020.100205
Abstract: Chronic Myelomonocytic Leukemia (CMML) is a blood malignancy that presents with splenomegaly in up to 40% of the patients; however, a pathological splenic rupture is very rare. We describe a 50-year-old male, who presented to… read more here.
Keywords: rupture; complication; splenic rupture; chronic myelomonocytic ... See more keywords
Blast Phase Chronic Myelomonocytic Leukemia: Mayo-MDACC Collaborative study of 171 cases
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DOI: 10.1038/s41375-018-0143-8
Abstract: Chronic myelomonocytic leukemia (CMML) is a clonal, hematopoietic stem cell disorder, characterized by sustained peripheral blood (PB) monocytosis and an inherent risk for blast phase (BP) disease.1, 2 Blast phase, as defined by ≥20% PB… read more here.
Keywords: phase; blast phase; myelomonocytic leukemia; chronic myelomonocytic ... See more keywords
Prognostic impact and timing considerations for allogeneic hematopoietic stem cell transplantation in chronic myelomonocytic leukemia
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DOI: 10.1038/s41408-020-00387-y
Abstract: Dear Editor, Chronic myelomonocytic leukemia (CMML) is a clonal disorder of aging hematopoietic stem cells characterized by overlapping features of myeloproliferation and myelodysplasia, with a median overall survival (OS) of ≤36 months. Hypomethylating agents (HMAs)… read more here.
Keywords: allogeneic hematopoietic; hematopoietic stem; chronic myelomonocytic; leukemia ... See more keywords
Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia
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DOI: 10.1038/s41467-017-02178-9
Abstract: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in JMML vary markedly from spontaneous resolution to rapid relapse after hematopoietic stem cell transplantation. Here, we… read more here.
Keywords: juvenile myelomonocytic; methylation; outcome; dna methylation ... See more keywords
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis
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DOI: 10.1038/s41467-021-23186-w
Abstract: Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRASG12D, define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays and a Vav-Cre-NrasG12D… read more here.
Keywords: plk1; ras mutations; chronic myelomonocytic; proliferative chronic ... See more keywords