Myeloperoxidase‐induced fibrinogen unfolding and clotting
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24107
Abstract: Due to its unique properties and high biomedical relevance fibrinogen is a promising protein for the development of various matrixes and scaffolds for biotechnological applications. Fibrinogen molecules may form extensive clots either upon specific cleavage… read more here.
Keywords: fibrinogen clotting; myeloperoxidase induced; fibrinogen; induced fibrinogen ... See more keywords
Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2626-8
Abstract: Myeloperoxidase (MPO) is a key enzyme in inflammatory and degenerative processes, although conflicting reports have been presented concerning its expression in the brain. We studied the cellular localization of MPO and compared numbers of MPO… read more here.
Keywords: myeloperoxidase; immunoreactive cells; alzheimer disease; affected neurodegeneration ... See more keywords
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4279-4
Abstract: Neutrophil elastase and myeloperoxidase enzymes have been implicated in high-fat diet-induced obesity, insulin resistance (IR) and atherosclerosis in animal models. The aim of the present study was to explore neutrophil elastase and myeloperoxidase mRNA expressions… read more here.
Keywords: overweight obese; myeloperoxidase; elastase myeloperoxidase; myeloperoxidase mrna ... See more keywords
The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.01.010
Abstract: Myeloperoxidase produces the two-electron oxidant HOCl, which targets plasmalogen phospholipids liberating 2-chlorofatty aldehyde. 2-Chlorofatty aldehyde has four known fates: 1) oxidation to 2-chlorofatty acid; 2) reduction to 2-chlorofatty alcohol; 3) Schiff base adduct formation with… read more here.
Keywords: myeloperoxidase; chlorinated lipidome; oxidation; chlorofatty acid ... See more keywords
Novel myeloperoxidase-derived HLA-A2-restricted peptides as therapeutic targets against myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2021.05.003
Abstract: BACKGROUND AIMS Human myeloperoxidase has been shown to be overexpressed in many types of leukemia, such as chronic myeloid leukemia, acute myeloid leukemia and myelodysplastic syndrome. The authors identified two myeloperoxidase-derived HLA-A2-restricted peptides, MY4 and… read more here.
Keywords: myeloperoxidase; myeloid leukemia; my8 specific; my4 my8 ... See more keywords
Deglycosylation of myeloperoxidase uncovers its novel antigenicity.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.12.012
Abstract: Myeloperoxidase (MPO) is a common target antigen of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and is recognized in one-third of patients with anti-glomerular basement membrane (GBM) disease. Our previous study identified over 60% of patients with… read more here.
Keywords: myeloperoxidase; gbm disease; glycosylated mpo; mpo ... See more keywords
C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.018
Abstract: The prospects for complement-targeted therapy in ANCA-associated vasculitis have been enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely replaced glucocorticoids in induction treatment. C5aR1 primes neutrophils for activation by… read more here.
Keywords: myeloperoxidase; anti myeloperoxidase; c5a receptor; inhibition ... See more keywords
Myeloperoxidase-Sensitive T1 and T2 Switchable MR Imaging for Diagnosis of Nonalcoholic Steatohepatitis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c06233
Abstract: Nonalcoholic steatohepatitis (NASH) is the critical stage in the development of nonalcoholic fatty liver disease (NAFLD) from simple and reversible steatosis to irreversible cirrhosis and even hepatocellular carcinoma (HCC). Thus, the diagnosis of NASH is… read more here.
Keywords: diagnosis; myeloperoxidase; nonalcoholic steatohepatitis; usio peg ... See more keywords
Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/nmicrobiol.2016.268
Abstract: Host control of infections crucially depends on the capability to kill pathogens with reactive oxygen species (ROS). However, these toxic molecules can also readily damage host components and cause severe immunopathology. Here, we show that… read more here.
Keywords: myeloperoxidase; salmonella; host; damage ... See more keywords
The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2114449
Abstract: Abstract Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For… read more here.
Keywords: paraoxonase; pregnant patients; oxidative stress; group ... See more keywords
Arterial myeloperoxidase in the detection and treatment of vulnerable atherosclerotic plaque: a new dawn for an old light.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac081
Abstract: Intracellular myeloperoxidase (MPO) plays a specific role in the innate immune response; however, upon release into the extracellular space in the setting of inflammation, drives oxidative tissue injury. Extracellular MPO has recently been shown to… read more here.
Keywords: atherosclerotic plaque; plaque; treatment vulnerable; myeloperoxidase ... See more keywords