Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
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DOI: 10.1038/s41467-020-15497-1
Abstract: Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link… read more here.
Keywords: myeloproliferation; via nlrp3; inflammasome activation; activation ... See more keywords