Association of Treatments for Myeloproliferative Neoplasms During Pregnancy With Birth Rates and Maternal Outcomes
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DOI: 10.1001/jamanetworkopen.2019.12666
Abstract: Key Points Question Are use of aspirin, heparin, interferon, or combinations associated with live birth rate and adverse maternal outcomes in pregnant women with myeloproliferative neoplasms? Findings In this systematic review and meta-analysis of 22… read more here.
Keywords: pregnancy; association treatments; birth; myeloproliferative neoplasms ... See more keywords
Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident
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DOI: 10.1002/ajh.25307
Abstract: Myeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL, and CALR genes; however, 10%‐15% of cases are triple negative (TN). A previous study showed lower rate of JAK2 V617F in primary myelofibrosis patients… read more here.
Keywords: patients exposed; ionizing radiation; rate; mpn patients ... See more keywords
Early‐onset severe infections in allogeneic hematopoietic stem cell transplantation recipients with graft failure
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DOI: 10.1002/ajh.25406
Abstract: REFERENCES 1. Srour SA, Devesa SS, Morton LM, et al. Incidence and patient survival of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms in the United States, 2001-12. Br J Haematol. 2016;174: 382-396. 2. Roaldsnes C, Holst R,… read more here.
Keywords: early onset; onset severe; severe infections; allogeneic hematopoietic ... See more keywords
PD‐L1 overexpression correlates with JAK2‐V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms
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DOI: 10.1002/ajh.26461
Abstract: Myeloproliferative neoplasms (MPN) are chronic stem cell disorders characterized by enhanced proliferation of myeloid cells, immune deregulation, and drug resistance. JAK2 somatic mutations drive the disease in 50–60% and CALR mutations in 25–30% of cases.… read more here.
Keywords: jak2; v617f mutational; jak2 v617f; myeloproliferative neoplasms ... See more keywords
Myeloproliferative neoplasms and splanchnic vein thrombosis: Contemporary diagnostic and therapeutic strategies
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DOI: 10.1002/ajh.26896
Abstract: Myeloproliferative neoplasms (MPNs) are the most common etiologies of primary splanchnic vein thrombosis, present in almost forty percent of patients with Budd‐Chiari syndrome or portal vein thrombosis. Diagnosis of MPNs can be difficult in these… read more here.
Keywords: neoplasms splanchnic; vein thrombosis; splanchnic vein; thrombosis ... See more keywords
Smoking is associated with increased risk of myeloproliferative neoplasms: A general population‐based cohort study
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DOI: 10.1002/cam4.1815
Abstract: Former studies on smoking as a risk factor for Philadelphia‐negative myeloproliferative neoplasms (MPNs) have mainly been carried out in women's cohorts and studies with various definitions of MPNs. Herein, we conducted a cohort study with… read more here.
Keywords: general population; myeloproliferative neoplasms; risk; cohort study ... See more keywords
MERGE: A Multinational, Multicenter Observational Registry for Myeloproliferative Neoplasms in Asia, including Middle East, Turkey, and Algeria
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DOI: 10.1002/cam4.3004
Abstract: Philadelphia chromosome‐negative (Ph−) myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders of the bone marrow, and are associated with a high disease burden, reduced quality of life (QOL), and shortened survival. This multinational,… read more here.
Keywords: asia including; east turkey; middle east; multinational multicenter ... See more keywords
Arginase‐1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver
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DOI: 10.1002/cam4.5542
Abstract: Philadelphia‐negative myeloproliferative neoplasms (MPN) are clonal myeloid proliferative disorders characterized by sustained systemic inflammation. Despite its renowned importance, the knowledge concerning the inflammatory pathophysiology of these conditions is currently limited to studies on serum cytokines,… read more here.
Keywords: bone marrow; myeloid cells; myeloid; marrow myeloid ... See more keywords
Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia
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DOI: 10.1002/cncr.31986
Abstract: Canonical Janus kinase 2 (JAK2) V617F and exon 12 mutations in myeloid neoplasms are well described. There are limited reports of other JAK2 variants of potential clinical relevance. This study was designed to survey JAK2… read more here.
Keywords: myeloproliferative neoplasms; myeloid leukemia; janus kinase; acute myeloid ... See more keywords
Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms
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DOI: 10.1002/hon.2622
Abstract: The 60th American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13th Post‐ASH chronic myeloproliferative neoplasms (MPNs) workshop on December 4 and 5, 2018. This closed annual workshop,… read more here.
Keywords: translational science; chronic myeloproliferative; treatment; myeloproliferative neoplasms ... See more keywords
Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology
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DOI: 10.1002/jcla.24289
Abstract: The present study aimed to explore the changes in the expressions of six tumor‐related genes in myeloproliferative neoplasms (MPNs). The study population included 130 patients with MPNs (52 with chronic myeloid leukemia (CML), 49 with… read more here.
Keywords: oncogenic tumor; suppressor genes; tumor suppressor; pathology ... See more keywords