The impact of long‐course chemoradiotherapy on the myenteric plexus, neuromuscular functions and responses to prokinetic drugs in the human rectum
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DOI: 10.1002/ueg2.12653
Abstract: Abstract Background & Aims The long‐term effects of chemoradiotherapy on human rectum are poorly understood. The aims were to investigate changes in inflammatory status, myenteric neuron numbers/phenotype, neuromuscular functions and prokinetic drug efficacy. Methods Macroscopically… read more here.
Keywords: neuromuscular functions; chemoradiotherapy; human rectum; rectum ... See more keywords
Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development
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DOI: 10.1093/hmg/ddx084
Abstract: &NA; For most multigenic disorders, clinical manifestation (penetrance) and presentation (expressivity) are likely to be an outcome of genetic interaction between multiple susceptibility genes. Here, using gene knockouts in mice, we evaluated genetic interaction between… read more here.
Keywords: myenteric plexus; genetic interaction; ret sema3d; interaction ... See more keywords
The P2Y1 receptor in the colonic myenteric plexus of rats and its correlation with opioid-induced constipation
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DOI: 10.1186/s12876-024-03119-9
Abstract: This study was designed to explore the expression changes of P2Y_1 receptors in the distal colonic myenteric layer of rats. An opioid induced constipation(OIC) rat model was generated by intraperitoneal (i.p) injection of loperamide. At… read more here.
Keywords: receptor; distal colonic; myenteric; myenteric plexus ... See more keywords