Intracranial vessel stenosis in a young patient with an MYH11 mutation: A case report and review of two prior cases.
Sign Up to like & getrecommendations! Published in 2020 at "World neurosurgery"
DOI: 10.1016/j.wneu.2020.02.054
Abstract: BACKGROUND The MYH11 gene codes for smooth muscle myosin heavy chain which has a critical function in maintaining vascular wall stability. Patients with this mutation most commonly have aortic and cardiac defects. Documented involvement of… read more here.
Keywords: myh11; stenosis young; stenosis; intracranial vessel ... See more keywords
Cryptic insertion of CBFB into MYH11 leading to a type D fusion in acute myeloid leukemia with normal karyotype
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13694
Abstract: Dear Editors, Acute myeloid leukemia (AML) with inv(16)(p13q22)/t(16;16) (p13;q22) has distinct clinicopathologic features, including myelomonocytic leukemic cells, abnormal bone marrow eosinophils, and a relatively favorable prognosis.1,2 Most cases are classified as AML M4 with abnormal… read more here.
Keywords: acute myeloid; fusion; myh11; insertion ... See more keywords
A New Autosomal Myh11-CreERT2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318160
Abstract: Background: The Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter available to study SMCs. Unfortunately, in the existing Myh11-CreERT2 mouse, the… read more here.
Keywords: creert2 rad; myh11 creert2; myh11; mice ... See more keywords
Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression
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DOI: 10.1186/s12885-021-08653-3
Abstract: Background Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at an advanced stage. The purpose of this study was to examine the expression of myosin heavy chain 11 (MYH11) in GC and mechanisms related.… read more here.
Keywords: dnmt3b; myh11 expression; gastric cancer; expression ... See more keywords
CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.675424
Abstract: A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2)… read more here.
Keywords: myh11 fusion; target genes; cbfb myh11; myh11 ... See more keywords