SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9‐Mediated GSK3β/β‐Catenin Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202203573
Abstract: Recurrence is a challenge to survival after the initial treatment of esophageal squamous cell carcinoma (ESCC). But, its mechanism remains elusive and there are currently no biomarkers to predict postoperative recurrence. Here, the possibility of… read more here.
Keywords: myh9; recurrence; postoperative recurrence; catenin ... See more keywords
MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11894
Abstract: MYH9 encodes the heavy chain of nonmuscle myosin IIA, a ubiquitously expressed cytoplasmic myosin that regulates the actin cytoskeleton, cell migration, cell polarization, and signal transduction in cancer cells. Here, we investigated the role of… read more here.
Keywords: myh9; pi3k akt; cell; akt mtor ... See more keywords
Efficacy of neutrophil non-muscle myosin heavy chain-IIA immunofluorescence analysis in determining the pathogenicity of MYH9 variants
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-2972-3
Abstract: Dear Editor, The recent advent of the next-generation sequencing (NGS) has revolutionized the way of genetic research and diagnosis for inherited diseases and several articles have emerged on the clinical application of targeted sequencing of… read more here.
Keywords: immunofluorescence analysis; analysis; myh9; determining pathogenicity ... See more keywords
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44194-3
Abstract: MYH9, a widely expressed gene encoding nonmuscle myosin heavy chain, is also expressed in podocytes and is associated with glomerular pathophysiology. However, the mechanisms underlying MYH9-related glomerular diseases associated with proteinuria are poorly understood. Therefore,… read more here.
Keywords: functional podocyte; myh9; mediated myh9; structural functional ... See more keywords
MYH9 gene mutations associated with bleeding
Sign Up to like & getrecommendations! Published in 2017 at "Platelets"
DOI: 10.1080/09537104.2017.1294250
Abstract: MYH9 is a large gene localized on chromosome 22q12.3-13.1 constituted of one 5ˊ-untranslated (exon 1) and 40 coding exons (Figure 1). It encodes for the heavy chain of the nonmuscle myosin IIA (NMMHC-IIA), a cytoplasmic… read more here.
Keywords: thrombocytopenia; myh9; nmmhc iia; nonhelical tail ... See more keywords
Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000018722
Abstract: Abstract The prevalence of risk factors of chronic kidney disease in Saudi Arabia has augmented an already serious public health problem, therefore, determination of genetic variants associated with the risk of the disease presents potential… read more here.
Keywords: myh9; risk; diabetic end; gene ... See more keywords
Aberrant adaptation of the inner medullary collecting ducts results in sodium retention and hypernatremia in a thick ascending limb specific Myh9 and Myh10 conditional knockout mouse model
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729973
Abstract: Sodium reabsorption in the thick ascending limb (TAL) epithelium is essential to generate and sustain the interstitial osmotic gradient, which facilitates water reabsorption in the adjacent collecting duct system. Impaired TAL function can compromise this… read more here.
Keywords: myh9; physiology; inner medullary; weeks age ... See more keywords
“MYH9 mutation and squamous cell cancer of the tongue in a young adult: a novel case report”
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Pathology"
DOI: 10.1186/s13000-022-01210-x
Abstract: Background The incidence of tongue cancer in young adults is on the rise. This trend is more pronounced in females. Although the aetiology is still unclear, there is mounting evidence that genetic syndromes can play… read more here.
Keywords: cancer; neck; tongue; myh9 ... See more keywords
MYH9 binds to dNTPs via deoxyribose moiety and plays an important role in DNA synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28219
Abstract: The accepted notion of dNTP transport following cytoplasmic biosynthesis is ‘facilitated diffusion’; however, whether this alone is sufficient for moving dNTPs for DNA synthesis remains an open question. The data presented here show that the… read more here.
Keywords: myh9; dna synthesis; binds dntps; role ... See more keywords
Identification of MYH9 Key Domain Involved in the Entry of PRRSV Into Permissive Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.865343
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen that causes huge losses economically to the pig industry worldwide. Previous research suggested that receptor dependence is necessary for PRRSV infection. MYH9 and CD163… read more here.
Keywords: myh9; prrsv infection; entry; domain ... See more keywords
ENKUR expression induced by chemically synthesized cinobufotalin suppresses malignant activities of hepatocellular carcinoma by modulating β-catenin/c-Jun/MYH9/USP7/c-Myc axis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.67476
Abstract: ENKUR plays a crucial role in lung and colorectal cancers. Chemically synthesized cinobufotalin (CB) showed its significant anti-cancer effect in nasopharyngeal carcinoma. However, the roles of ENKUR and CB along with their correlation are still… read more here.
Keywords: myh9; enkur expression; expression; catenin ... See more keywords