Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice
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DOI: 10.1038/s41467-024-50036-2
Abstract: The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly… read more here.
Keywords: aneurysm dissection; mir 1204; aortic aneurysm; mylk ... See more keywords
The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0141oc
Abstract: &NA; Profound lung vascular permeability is a cardinal feature of acute respiratory distress syndrome (ARDS) and ventilator‐induced lung injury (VILI), two syndromes known to centrally involve the nonmuscle isoform of myosin light chain kinase (nmMLCK)… read more here.
Keywords: splicing factor; mylk; mylk splicing; role ... See more keywords
Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions
Sign Up to like & getrecommendations! Published in 2018 at "Pulmonary Circulation"
DOI: 10.1177/2045894018764171
Abstract: Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y464 and Y471… read more here.
Keywords: myosin light; mylk; mylk coding; light chain ... See more keywords