The MyMOMA domain of MYO19 encodes for distinct Miro‐dependent and Miro‐independent mechanisms of interaction with mitochondrial membranes
Sign Up to like & getrecommendations! Published in 2019 at "Cytoskeleton"
DOI: 10.1002/cm.21560
Abstract: MYO19 interacts with mitochondria through a C‐terminal membrane association domain (MyMOMA). Specific mechanisms for localization of MYO19 to mitochondria are poorly understood. Using promiscuous biotinylation data in combination with existing affinity‐capture databases, we have identified… read more here.
Keywords: miro2; 970 gfp; myo19898 970; myo19 ... See more keywords
Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260612
Abstract: Mitochondrial homeostasis requires a dynamic balance of fission and fusion. The actin cytoskeleton promotes fission; we find that the mitochondrially-localized myosin, Myosin 19 (Myo19), is integral to this process. Myo19 knock-down induces mitochondrial elongation, while… read more here.
Keywords: myo19; endoplasmic reticulum; fission; myo19 tethers ... See more keywords