Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.06.008
Abstract: BACKGROUND & AIM Myosin VB (MYO5B) is an essential trafficking protein for membrane recycling in gastrointestinal epithelial cells. The inactivating mutations of MYO5B cause the congenital diarrheal disease, microvillus inclusion disease (MVID). MYO5B deficiency in… read more here.
Keywords: microvillus inclusion; inclusion disease; mice; myo5b ... See more keywords
LPAR5 agonist, Compound-1, treatment ameliorates epithelial cell deficits in MYO5B knockout mice and enteroids
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732933
Abstract: Functional loss of a motor protein, Myosin Vb (MYO5B), induces a variety of deficits in intestinal epithelial function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). Using the tamoxifen-induced epithelial-specific MYO5B-deficient ( Villin-CreERT2;Myo5bflox/flox)… read more here.
Keywords: compound; myo5b; myo5b deficient; loss ... See more keywords
Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation
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DOI: 10.1371/journal.pbio.3000531
Abstract: Recycling endosomes regulate plasma membrane recycling. Recently, recycling endosome–associated proteins have been implicated in the positioning and orientation of the mitotic spindle and cytokinesis. Loss of MYO5B, encoding the recycling endosome–associated myosin Vb, is associated… read more here.
Keywords: orientation; loss myo5b; myo5b expression; myo5b ... See more keywords
Bioinformatics reveal elevated levels of Myosin Vb in uterine corpus endometrial carcinoma patients which correlates to increased cell metabolism and poor prognosis
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DOI: 10.1371/journal.pone.0280428
Abstract: Carcinoma of the endometrium of the uterus is the most common female pelvic malignancy. Although uterine corpus endometrial cancer (UCEC) has a favorable prognosis if removed early, patients with advanced tumor stages have a low… read more here.
Keywords: myo5b; metabolism; prognosis; ucec patients ... See more keywords