FTO overexpression inhibits apoptosis of hypoxia/reoxygenation-treated myocardial cells by regulating m6A modification of Mhrt.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04069-6
Abstract: Heart failure (HF) is the end stage of many cardiovascular diseases and seriously threatens people's health. This article aimed to explore the biological role of fat-mass and obesity-associated gene (FTO) in HF. We constructed HF… read more here.
Keywords: treated myocardial; hypoxia reoxygenation; fto overexpression; myocardial cells ... See more keywords
iKeap1 activates Nrf2 signaling to protect myocardial cells from oxygen glucose deprivation/re-oxygenation-induced oxidative injury.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.024
Abstract: Nuclear factor E2-related factor 2 (Nrf2) activation could efficiently protect myocardial cells from oxygen glucose deprivation/re-oxygenation (OGDR). An ultra-large structure-based virtual screening has discovered iKeap1 as a novel, direct and potent Keap1 inhibitor. Here we… read more here.
Keywords: induced oxidative; nrf2 signaling; myocardial cells; protect myocardial ... See more keywords
Low-expressed GAS5 injure myocardial cells and progression of chronic heart failure via regulation of miR-223-3P.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104529
Abstract: Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment.… read more here.
Keywords: gas5; heart failure; myocardial cells; chf ... See more keywords
Simulation of hypoxia of myocardial cells in microfluidic systems
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72660-w
Abstract: The paper presents a newly designed microfluidic system that allows simulation of myocardial hypoxia by biochemical method. The geometry of the microsystem was designed in such a way, that quantitative fluorescent measurements using a spectrofluorometric… read more here.
Keywords: hypoxia myocardial; simulation hypoxia; cells microfluidic; myocardial cells ... See more keywords
Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1138709
Abstract: Objective To explore the inhibitor effects and mechanism of lncRNA 93358 against the apoptosis of myocardial cells in rats with myocardial infarction. Methods The myocardial infarction model was established in rats, which were identified by… read more here.
Keywords: slc8a1; myocardial cells; apoptosis myocardial; myocardial infarction ... See more keywords
Developmental changes in myocardial B cells mirror changes in B cells associated with different organs
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.139377
Abstract: The naive heart harbors a population of intravascular B cells that make close contact with the cardiac microvasculature. However, the timing of their appearance and their organ specificity remain unknown. To address this knowledge gap,… read more here.
Keywords: heart; analysis; myocardial cells; developmental changes ... See more keywords
Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide.
Sign Up to like & getrecommendations! Published in 2018 at "International heart journal"
DOI: 10.1536/ihj.16-372
Abstract: The aim of this study was to investigate the effects of taurine (Tau) on primary cultured neonatal myocardial cells treated with hydrogen peroxide (H2O2) and the underlying mechanism. Primary cardiac myocytes from neonatal Wistar rats… read more here.
Keywords: hydrogen peroxide; myocardial cells; expression; taurine ... See more keywords
MiR-31a-5p protects myocardial cells against apoptosis by targeting Tp53.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8357
Abstract: The pathogenesis and progression of heart failure (HF) involves multiple mechanisms, including the increased activity of the renin-angiotensin-aldosterone system, apoptosis and differential expression of microRNAs (miRNAs/miRs). Our previous study revealed an increase in miR‑31a‑5p levels… read more here.
Keywords: myocardial cells; seed; mir 31a; targeting tp53 ... See more keywords