Relation between post‐myocardial infarct remodelling and gelatinase activity in patients enrolled in the TIPTOP trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1361
Abstract: In pre-clinical studies, matrix metalloproteinase (MMP) inhibition, particularly gelatinases (MMP-2 and -9), attenuated post-myocardial infarct (MI) remodelling.1 However, synthetic inhibitors of MMPs in the clinical setting have yielded disappointing results.2 For the first time, the… read more here.
Keywords: trial; mmp; post myocardial; post ... See more keywords
Nonbinary quantification technique accounting for myocardial infarct heterogeneity: Feasibility of applying percent infarct mapping in patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25973
Abstract: Binary threshold‐based quantification techniques ignore myocardial infarct (MI) heterogeneity, yielding substantial misquantification of MI. read more here.
Keywords: nonbinary quantification; myocardial infarct; infarct heterogeneity;
High‐resolution mapping of sensory fibers at the healthy and post‐myocardial infarct whole transgenic hearts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25150
Abstract: The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2‐expressing cardiac afferent fibers of spinal and vagal origin… read more here.
Keywords: innervation; transgenic hearts; myocardial infarct; high resolution ... See more keywords
Effects of OP2113 on Myocardial Infarct Size and No Reflow in a Rat Myocardial Ischemia/Reperfusion Model
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07113-7
Abstract: The present study was to determine whether OP2113 could limit myocardial infarction size and the no-reflow phenomenon in a rat myocardial ischemia/reperfusion model. Rat heart–isolated mitochondria (RHM) were used to investigate mitochondrial respiration and mitochondrial… read more here.
Keywords: infarct size; reperfusion; size; ischemia reperfusion ... See more keywords
GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.049
Abstract: Aims: Estrogen plays an important role in cardioprotection. Animal experiments showed that the G‐protein coupled estrogen receptor 30 (GPR30) specific agonist G1 could reduce post‐ischemic dysfunction and inhibit cardiac fibroblast proliferation. However, the underlying mechanism… read more here.
Keywords: fibrosis; area; pi3k akt; mice ... See more keywords
Functional capacity in a rat model of heart failure: impact of myocardial infarct size
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Physiology"
DOI: 10.1113/ep086076
Abstract: What is the central question of this study? To the best of our knowledge, no studies have evaluated oxygen uptake, carbon dioxide production and exercise tolerance in rats that have undergone myocardial infarction classified by… read more here.
Keywords: size; myocardial infarct; infarct size; functional capacity ... See more keywords
Abstract 16538: Circulating Ketone Levels are Associated With Myocardial Infarct Size and Left Ventricular Function in Patients Presenting With St-Elevation Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16538
Abstract: Background: Circulating ketone bodies (KB) are increased in patients with heart failure, corresponding with increased utilization of KB as a cardiac fuel. Whether circulating KB are increased in patients presenting with ST-elevation myocardial infarction (STEMI)… read more here.
Keywords: elevation myocardial; infarct; infarct size; myocardial infarct ... See more keywords
CMRSegTools: An open-source software enabling reproducible research in segmentation of acute myocardial infarct in CMR images
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274491
Abstract: In the last decade, a large number of clinical trials have been deployed using Cardiac Magnetic Resonance (CMR) to evaluate cardioprotective strategies aiming at reducing the irreversible myocardial damage at the time of reperfusion. In… read more here.
Keywords: software; myocardial infarct; source; lesion ... See more keywords
Effects of Ticagrelor on Myocardial Infarct Size
Sign Up to like & getrecommendations! Published in 2017 at "Korean Circulation Journal"
DOI: 10.4070/kcj.2017.0161
Abstract: Ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA) is a direct acting, reversible, oral P2Y12 inhibitor.1) In the PLATelet inhibition and patient Outcomes (PLATO) study, compared to clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals, Bridgewater, NJ, USA),… read more here.
Keywords: effects ticagrelor; ticagrelor; myocardial infarct; infarct size ... See more keywords