Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120371
Abstract: BACKGROUND Neonatal hearts have considerable regenerative potential within 7 days post birth (P7), but the rate of regeneration is extremely low after P7. Interestingly, lipid metabolism increases dramatically after P7. The similarities in these age profiles… read more here.
Keywords: acsl1; myocardial regeneration; lipid metabolism; cardiac regeneration ... See more keywords
Achieving stable myocardial regeneration after apical resection in neonatal mice
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DOI: 10.1111/jcmm.15223
Abstract: The neonatal heart completely regenerates after apical resection (AR), providing a desirable research model to study the mechanism of cardiac regeneration and cardiomyocyte proliferation. However, AR‐induced neonatal heart regenerative phenomenon is controversial due to the… read more here.
Keywords: heart; apical resection; myocardial regeneration; regeneration ... See more keywords
How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/7874109
Abstract: Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the… read more here.
Keywords: stem cell; cell; heart; myocardial regeneration ... See more keywords
P16INK4a Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy
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DOI: 10.1155/2023/1696190
Abstract: Neonatal mice achieve complete cardiac repair through endogenous myocardial regeneration after apical resection (AR), but this capacity is rapidly lost 7 days after birth. As an upstream inhibitor of cyclin-dependent kinase 4/6- (CDK4/6-) mediated cell… read more here.
Keywords: cdk4 mediated; p16ink4a; regeneration; proliferation ... See more keywords
Abstract 12931: Myocardial Regeneration in End-stage Heart Failure After Left Ventricular Unloading
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DOI: 10.1161/circ.142.suppl_3.12931
Abstract: Introduction: Left Ventricular Assist Devices (LVAD) decrease cardiac mechanical work and metabolic demand and may decrease cardiomyocyte oxidative stress, followed by cell cycle re-entry and cell regeneration. We tested whether LVAD long-term support is associated… read more here.
Keywords: end stage; low intensity; myocardial regeneration; regeneration ... See more keywords
An overview of the myocardial regeneration potential of cardiac c-Kit+ progenitor cells via PI3K and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Future cardiology"
DOI: 10.2217/fca-2018-0049
Abstract: In recent years, several studies have investigated cell transplantation as an innovative strategy to restore cardiac function following heart failure. Previous studies have also shown cardiac progenitor cells as suitable candidates for cardiac cell therapy… read more here.
Keywords: progenitor cells; myocardial regeneration; pi3k mapk; regeneration potential ... See more keywords
Unraveling and Targeting Myocardial Regeneration Deficit in Diabetes
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DOI: 10.3390/antiox11020208
Abstract: Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction without coronary atherosclerosis and hypertension is driven by hyperglycemia, hyperinsulinemia and impaired insulin signaling. Cardiomyocyte death, hypertrophy, fibrosis, and cell signaling defects underlie cardiomyopathy. Notably,… read more here.
Keywords: unraveling targeting; regeneration deficit; targeting myocardial; myocardial regeneration ... See more keywords