Mechanosensitive molecular mechanisms of myocardial fibrosis in living myocardial slices
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13832
Abstract: Altered mechanical load in response to injury is a main driver of myocardial interstitial fibrosis. No current in vitro model can precisely modulate mechanical load in a multicellular environment while maintaining physiological behaviour. Living myocardial… read more here.
Keywords: myocardial slices; myocardial fibrosis; molecular mechanisms; mechanosensitive molecular ... See more keywords
Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10175-3
Abstract: Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the… read more here.
Keywords: electromechanical stimulation; adult; adult cardiac; cardiac tissue ... See more keywords
Living myocardial slices: Advancing arrhythmia research
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1076261
Abstract: Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation… read more here.
Keywords: arrhythmia research; myocardial slices; slices advancing; living myocardial ... See more keywords