Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
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DOI: 10.1016/j.isci.2021.102739
Abstract: Summary Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the transcriptional… read more here.
Keywords: mrtf; turnover; related transcription; factor ... See more keywords
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy
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DOI: 10.1161/circulationaha.117.031788
Abstract: Background: Hypertrophic cardiomyocyte growth and dysfunction accompany various forms of heart disease. The mechanisms responsible for transcriptional changes that affect cardiac physiology and the transition to heart failure are not well understood. The intercalated disc… read more here.
Keywords: heart; microscopy; physiology; related transcription ... See more keywords
Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes
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DOI: 10.3390/ijms23137394
Abstract: Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics that are controlled by Rho GTPases. SRF is a ubiquitous transcription factor strongly expressed in muscular tissues. The… read more here.
Keywords: myocardin related; shuttling; actin; cardiac actin ... See more keywords