Antioxidant N‐acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.034
Abstract: &NA; Increased oxidative stress and myocyte autophagy co‐exist in cardiac remodeling. However, it is unclear whether oxidative stress mediates maladaptive myocyte autophagy in pathological ventricular remodeling. In this study, we tested the hypothesis that antioxidants… read more here.
Keywords: myocyte autophagy; maladaptive myocyte; pressure overload; myocyte ... See more keywords
Regional variations in left ventricular myocyte diameter and nuclear length in post mortem population: implications in assessing myocyte hypertrophy
Sign Up to like & getrecommendations! Published in 2024 at "Australian Journal of Forensic Sciences"
DOI: 10.1080/00450618.2024.2354206
Abstract: ABSTRACT Cardiac hypertrophy can be appreciated microscopically by assessing for myocyte hypertrophy. Features of myocyte hypertrophy include increased myocyte diameter, together with increase in nuclear hyperchromicity, size and irregularity, and an increase in binucleated myocytes.… read more here.
Keywords: assessing myocyte; hypertrophy; myocyte diameter; myocyte hypertrophy ... See more keywords
β-Adrenergic Receptors - Not Always Outside-In.
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.00019.2025
Abstract: Canonical activation of G-protein coupled receptors (GPCRs) by hormone binding occurs at the plasma membrane, resulting in the diffusion of second messengers to intracellular effector sites throughout the cell. In contrast, recent evidence suggests that… read more here.
Keywords: physiology; receptors always; always outside; myocyte ... See more keywords
Ninjurin1 regulates striated muscle growth and differentiation
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DOI: 10.1371/journal.pone.0216987
Abstract: Chronic pressure overload due to aortic valve stenosis leads to pathological cardiac hypertrophy and heart failure. Hypertrophy is accompanied by an increase in myocyte surface area, which requires a proportional increase in the number of… read more here.
Keywords: ninjurin1; muscle; hypertrophy; differentiation ... See more keywords
Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom13010072
Abstract: Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity. Functional characterization… read more here.
Keywords: cpvt4; myocyte; calcium; type ... See more keywords
Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes14010023
Abstract: Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that… read more here.
Keywords: myocyte; computational model; pig ventricular; mutation ... See more keywords