Antioxidant N‐acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.034
Abstract: &NA; Increased oxidative stress and myocyte autophagy co‐exist in cardiac remodeling. However, it is unclear whether oxidative stress mediates maladaptive myocyte autophagy in pathological ventricular remodeling. In this study, we tested the hypothesis that antioxidants… read more here.
Keywords: myocyte autophagy; maladaptive myocyte; pressure overload; myocyte ... See more keywords
Ninjurin1 regulates striated muscle growth and differentiation
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DOI: 10.1371/journal.pone.0216987
Abstract: Chronic pressure overload due to aortic valve stenosis leads to pathological cardiac hypertrophy and heart failure. Hypertrophy is accompanied by an increase in myocyte surface area, which requires a proportional increase in the number of… read more here.
Keywords: ninjurin1; muscle; hypertrophy; differentiation ... See more keywords
Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte
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DOI: 10.3390/biom13010072
Abstract: Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity. Functional characterization… read more here.
Keywords: cpvt4; myocyte; calcium; type ... See more keywords
Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model
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DOI: 10.3390/genes14010023
Abstract: Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that… read more here.
Keywords: myocyte; computational model; pig ventricular; mutation ... See more keywords