Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle
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DOI: 10.1038/s41598-021-95378-9
Abstract: Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective membrane repair, and calcium mishandling.… read more here.
Keywords: loss dysferlin; muscle; myoferlin; dysferlin myoferlin ... See more keywords
O48: MYOFERLIN: A NOVEL PREDICTIVE BIOMARKER AND THERAPEUTIC TARGET IN ADVANCED COLORECTAL CANCER
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DOI: 10.1093/bjs/znab117.048
Abstract: Myoferlin is a protein involved in cell proliferation, migration and angiogenesis, which are essential in tumour metastasis. Its expression correlates with a poorer prognosis in various epithelial cancers, but has yet to be associated with… read more here.
Keywords: therapeutic target; rectal cancer; cancer; lymph nodes ... See more keywords
Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration
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DOI: 10.3389/fonc.2022.905230
Abstract: Objective In contrast to normal cells, in which reactive oxygen species (ROS) are maintained in redox equilibrium, cancer cells are characterized by ectopic ROS accumulation. Myoferlin, a newly identified oncogene, has been associated with tumor… read more here.
Keywords: redox equilibrium; migration; gastric cancer; cancer ... See more keywords
c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression
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DOI: 10.3390/cancers14041095
Abstract: Simple Summary Receptor tyrosine kinases are essential for the development, growth, and progression of clear cell renal cell carcinoma (ccRCC). Targeted therapies using receptor tyrosine kinase inhibitors are widely used in ccRCC treatment. Myoferlin is… read more here.
Keywords: cell; receptor tyrosine; myoferlin; expression ... See more keywords