Inhibitors of the ubiquitin proteasome system block myofibril assembly in cardiomyocytes derived from chick embryos and human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21697
Abstract: Details of sarcomeric protein assembly during de novo myofibril formation closely resemble myofibrillogenesis in skeletal and cardiac myocytes in birds, rodents, and zebrafish. The arrangement of proteins during myofibrillogenesis follows a three‐step process: beginning with… read more here.
Keywords: myofibril; ubiquitin proteasome; human cardiomyocytes; cardiomyocytes derived ... See more keywords
STED analysis reveals the organization of nonmuscle muscle II, muscle myosin II, and F‐actin in nascent myofibrils
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DOI: 10.1002/cm.21729
Abstract: A three‐step model has been proposed to describe myofibril assembly in vertebrate cardiac and skeletal muscle cells beginning with premyofibrils, followed by nascent myofibrils, and ending as mature myofibrils (reviewed in Sanger, Wang, et al.… read more here.
Keywords: nascent myofibrils; myofibril; muscle; muscle myosin ... See more keywords
Mechanical forces during muscle development
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2016.11.003
Abstract: Muscles are the major force producing tissue in the human body. While certain muscle types specialize in producing maximum forces, others are very enduring. An extreme example is the heart, which continuously beats for the… read more here.
Keywords: mechanical forces; muscle; myofibril; forces muscle ... See more keywords
Progressive Myofibril Reorganization of Human Cardiomyocytes on a Dynamic Nano-topographic Substrate.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c03464
Abstract: Cardiomyocyte (CM) alignment with striated myofibril organization is developed during early cardiac organogenesis. Previous work has successfully achieved in vitro CM alignment using a variety of biomaterial scaffolds and substrates with static topographic features. However,… read more here.
Keywords: myofibril reorganization; response; topographic substrate; alignment ... See more keywords
Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental biology"
DOI: 10.2139/ssrn.4349476
Abstract: Slow myosin heavy chain 1 (Smyhc1) is the major sarcomeric myosin driving early contraction by slow skeletal muscle fibres in zebrafish. New mutant alleles lacking a functional smyhc1 gene move poorly, but recover motility as… read more here.
Keywords: heavy chain; myofibril; muscle; myosin heavy ... See more keywords
Shrinkage Properties and Their Relationship with Degradation of Proteins Linking the Endomysium and Myofibril in Lamb Meat Submitted to Heating or Air Drying
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DOI: 10.3390/foods11152242
Abstract: The shrinkage of the connective tissue and myofiber of lamb meat submitted to heat treatment or air drying at different storage stages (1, 5 and 7 days) was evaluated herein. The longitudinal and transverse shrinkage… read more here.
Keywords: myofibril; degradation proteins; shrinkage; lamb meat ... See more keywords
Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila
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DOI: 10.7554/elife.35783
Abstract: We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated. These muscles revealed new functions for IAPs not required for… read more here.
Keywords: drosophila; functions integrin; associated proteins; myofibril ... See more keywords