Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32376
Abstract: Myofibroblasts are a population of highly contractile fibroblasts that express and require the activity of the transcription factor Snail1. Cancer‐associated fibroblasts (CAFs) correlate with low survival of cancer patients when present in the stroma of… read more here.
Keywords: fibrosis; snail1; methyltransferase; myofibroblast ... See more keywords
Tumor necrosis factor alpha and interleukin 1 beta suppress myofibroblast activation via nuclear factor kappa B signaling in 3D-cultured mitral valve interstitial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.075
Abstract: Mitral valve disease is a major cause of cardiovascular morbidity throughout the world. Many different mitral valve pathologies feature fibrotic remodeling, often accompanied by an inflammatory state. Mitral valve fibrosis is mediated by valvular interstitial… read more here.
Keywords: interstitial cells; mitral valve; myofibroblast; valve disease ... See more keywords
Simvastatin and the Rho‐kinase inhibitor Y‐27632 prevent myofibroblast transformation in Peyronie's disease‐derived fibroblasts via inhibition of YAP/TAZ nuclear translocation
Sign Up to like & getrecommendations! Published in 2019 at "BJU International"
DOI: 10.1111/bju.14638
Abstract: To uncover the anti‐myofibroblast (MFB) properties of Rho‐kinase inhibitor (compound Y‐27632) and simvastatin in an in vitro model of Peyronie's disease (PD), a sexually debilitating disease caused by an irreversible fibrotic plaque in the penile… read more here.
Keywords: disease; kinase inhibitor; myofibroblast; peyronie disease ... See more keywords
Tracing causes of tubule atrophy in vivo
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734090
Abstract: Acute kidney injury (AKI) is a known risk factor for chronic kidney disease (CKD). The mechanisms for AKI-CKD transition may involve failed tubule repair and progressive interstitial fibrosis but are incompletely understood. Which events lead… read more here.
Keywords: kidney; tubule atrophy; myofibroblast; physiology ... See more keywords
Myofibroblast-Specific TGF&bgr; Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.313089
Abstract: Rationale: Hypertrophic cardiomyopathy occurs with a frequency of about 1 in 500 people. Approximately 30% of those affected carry mutations within the gene encoding cMyBP-C (cardiac myosin binding protein C). Cardiac stress, as well as… read more here.
Keywords: myofibroblast specific; fibrotic response; myofibroblast; mybpc340kda ... See more keywords
Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.517
Abstract: Cardiac fibrosis occurs in ischemic heart failure, genetic cardiomyopathies, diabetes, and aging. While initially considered reparative, resident cardiac fibroblasts (CFs) activation/differentiation to myofibroblasts provide contractile and integral support; however, persistent activation leads to progressive cardiac… read more here.
Keywords: myofibroblast; stress; differentiation; persistence ... See more keywords
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150323
Abstract: Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on mesenchymal lineage cells that provide a supportive microenvironment for hematopoiesis and angiogenesis… read more here.
Keywords: bone marrow; bone; myofibroblast; radiation ... See more keywords
Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.164862
Abstract: Vascular smooth muscle–derived Sca1+ adventitial progenitor (AdvSca1-SM) cells are tissue-resident, multipotent stem cells that contribute to progression of vascular remodeling and fibrosis. Upon acute vascular injury, AdvSca1-SM cells differentiate into myofibroblasts and are embedded in… read more here.
Keywords: myofibroblast; progenitor; differentiation; brg1 ... See more keywords
The Human Myofibroblast Marker Xylosyltransferase-I: A New Indicator for Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112869
Abstract: Chronic inflammation and excessive synthesis of extracellular matrix components, such as proteoglycans (PG), by fibroblast- or macrophage-derived myofibroblasts are the hallmarks of fibrotic diseases, including systemic sclerosis (SSc). Human xylosyltransferase-I (XT-I), which is encoded by… read more here.
Keywords: myofibroblast marker; macrophage polarization; myofibroblast; macrophage ... See more keywords
Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ETAR/Gαq/ERK Signaling Pathway in Human Cardiac Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054475
Abstract: Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast differentiation, which is mainly characterized by an overexpression of α-smooth muscle… read more here.
Keywords: myofibroblast differentiation; cell proliferation; proliferation; myofibroblast ... See more keywords