Atrial myofibroblast activation and connective tissue formation in a porcine model of atrial fibrillation and reduced left ventricular function
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.025
Abstract: Aims: Atrial fibrillation (AF) is associated with fibrosis that slows electrical conduction and causes perpetuation of the arrhythmia. The molecular characterization of AF pathophysiology may provide novel therapeutic options. This study was designed to elucidate… read more here.
Keywords: atrial fibrillation; model atrial; myofibroblast activation; porcine model ... See more keywords
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4419
Abstract: Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodeling by activated myofibroblasts, leads to loss of proper tissue architecture and organ… read more here.
Keywords: fibrosis; myofibroblast activation; activation; adam10 mediated ... See more keywords
RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.209932
Abstract: ABSTRACT Myofibroblasts play key roles in wound healing and pathological fibrosis. Here, we used an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify α-smooth muscle actin stress fibers in… read more here.
Keywords: myofibroblast activation; fibrosis; stat3; rnai ... See more keywords