Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202007798
Abstract: Inhibiting the myofibroblast differentiation of lung-resident mesenchymal stem cells (LR-MSCs) is a promising yet challenging approach for pulmonary fibrosis (PF) therapy. Here, micelles formed by a graft copolymer of multiple PEGs modified branched polyethylenimine are… read more here.
Keywords: myofibroblast differentiation; fibrosis therapy; small interfering; pulmonary fibrosis ... See more keywords
Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23074
Abstract: Statins have anti‐inflammatory and antifibrotic effects in addition to cholesterol‐lowering effect. We aimed to investigate the effect of atorvastatin (ATR) in fibrotic mouse lung and human lung fibroblasts (MRC5s). Pulmonary fibrosis was induced by a… read more here.
Keywords: myofibroblast differentiation; apoptosis; pulmonary fibrosis; mice ... See more keywords
CGRP induces myofibroblast differentiation and the production of extracellular matrix in MRC5s via autocrine and paracrine signalings
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23204
Abstract: There are contradictory views on which calcitonin gene‐related peptide (CGRP) causes pulmonary fibrosis. Fibrotic potency of CGRP was tested and compared to that of transforming growth factor‐β (TGF‐β). Myofibroblast differentiation, cell proliferation, and activations of… read more here.
Keywords: myofibroblast differentiation; extracellular matrix; cgrp; production ... See more keywords
The Novel mTOR Complex 1/2 Inhibitor P529 Inhibits Human Lung Myofibroblast Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25878
Abstract: Idiopathic pulmonary fibrosis is a progressive and deadly disorder with very few therapeutic options. Palomid 529 (8‐(1‐hydroxyethyl)‐2‐methoxy‐3‐(4‐methoxybenzyloxy)‐benzo[c]chromen‐6‐one; P529) is a novel dual inhibitor of mechanistic target of rapamycin complex 1/2 (mTORC1/2). In these studies, we… read more here.
Keywords: myofibroblast differentiation; human lung; tgf induced; p529 ... See more keywords
Matrix Adhesiveness Regulates Myofibroblast Differentiation from Vocal Fold Fibroblasts in a Bio-orthogonally Cross-linked Hydrogel.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c13852
Abstract: Repeated mechanical and chemical insults cause an irreversible alteration of extracellular matrix (ECM) composition and properties, giving rise to vocal fold scarring that is refractory to treatment. Although it is well known that fibroblast activation… read more here.
Keywords: myofibroblast differentiation; hydrogel; rgdsp; vocal fold ... See more keywords
Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43213
Abstract: Nicotine is the major stimulant in tobacco products including e-cigarettes. Fibroblast to myofibroblast differentiation is a key process during wound healing and is dysregulated in lung diseases. The role of nicotine and e-cigarette derived nicotine… read more here.
Keywords: myofibroblast differentiation; nicotine cigarette; differentiation; complex iii ... See more keywords
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1328348
Abstract: ABSTRACT Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor β) is one of the major profibrotic cytokines for myofibroblast differentiation and… read more here.
Keywords: myofibroblast differentiation; azm; fibrosis; lung fibrosis ... See more keywords
Autophagy drives fibroblast senescence through MTORC2 regulation
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1713640
Abstract: ABSTRACT Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, we evaluate the relationship between… read more here.
Keywords: myofibroblast differentiation; kinase; senescence; autophagy ... See more keywords
ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046448
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration are major clinical manifestations of this disease; hence, blocking these processes is a practical… read more here.
Keywords: pulmonary fibrosis; myofibroblast differentiation; linc00941; elavl1 ... See more keywords
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.210356
Abstract: Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause… read more here.
Keywords: myofibroblast differentiation; extracellular matrix; fibroblast myofibroblast; tissue ... See more keywords
Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb5069
Abstract: Tissue-engineered fibrosis model highlights distinct cell responses to matrix stiffness and drug treatment in 2D versus 3D. Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly… read more here.
Keywords: myofibroblast differentiation; fibrosis; matrix; microengineered pulmonary ... See more keywords