Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients
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DOI: 10.1038/s41598-019-41153-w
Abstract: Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology, the effect of in vitro… read more here.
Keywords: ssc dermal; disease; systemic sclerosis; myofibroblast phenotype ... See more keywords
Ascorbic acid promotes a TGFβ1‐induced myofibroblast phenotype switch
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DOI: 10.14814/phy2.13324
Abstract: l‐Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl‐3‐hydroxylase (P3H), prolyl‐4‐hydroxylase (P4H), and lysyl hydroxylase (LH)‐mediated collagen maturation. Here, we investigated whether AA has additional… read more here.
Keywords: phenotype; ascorbic acid; myofibroblast phenotype; tgf induced ... See more keywords