EPO synthesis induced by HIF‐PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non‐injured nephron segments in murine kidney fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13826
Abstract: Erythropoietin (EPO) is regulated by hypoxia‐inducible factor (HIF)‐2. In the kidney, it is produced by cortico‐medullary perivascular interstitial cells, which transdifferentiate into collagen‐producing myofibroblasts in response to injury. Inhibitors of prolyl hydroxylase domain (PHD) dioxygenases… read more here.
Keywords: epo synthesis; kidney; kidney fibrosis; myofibroblast transdifferentiation ... See more keywords
The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14006
Abstract: Renal fibrosis is the common final pathway of various chronic kidney diseases (CKDs), irrespective of the initial causes of nephropathy. Decline of renal function, glomerular filtration rate, has been exhibited to be highly associated with… read more here.
Keywords: pathway; myofibroblast transdifferentiation; fibrosis; dipyridamole ... See more keywords
PGE2 and thrombin induce myofibroblast transdifferentiation via activinA and CTGF in endometrial stromal cells.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqab207
Abstract: Endometriosis is characterized by inflammation and fibrotic changes. Our previous study using a mouse model showed that proinflammatory factors present in peritoneal hemorrhage exacerbated inflammation in endometriosis-like grafts, at least in part through the activation… read more here.
Keywords: endometriosis; pge2 thrombin; stromal cells; endometrial stromal ... See more keywords
Myofibroblast transdifferentiation is associated with changes in cellular and extracellular vesicle miRNA abundance
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0256812
Abstract: Transforming growth factor-beta 1 (TGF-β1), a pro-fibrotic tumour-derived factor promotes fibroblast differentiation in the tumour microenvironment and is thought to contribute to the development of pro-tumourigenic cancer-associated fibroblasts (CAFs) by promoting myofibroblast differentiation. miRNA dysregulation… read more here.
Keywords: mirna; oral fibroblasts; associated changes; expression ... See more keywords
Myofibroblast transdifferentiation of keratocytes results in slower migration and lower sensitivity to mesoscale curvatures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.930373
Abstract: Functional tissue repair after injury or disease is governed by the regenerative or fibrotic response by cells within the tissue. In the case of corneal damage, keratocytes are a key cell type that determine the… read more here.
Keywords: fibroblastic keratocytes; myofibroblastic keratocytes; slower migration; migration ... See more keywords
JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
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DOI: 10.3390/ijms22062952
Abstract: Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts is known to dominate tissue remodeling and fibrosis in Graves’ ophthalmopathy (GO). However, the signaling pathways through which TGF-β1 activates Graves’ orbital fibroblasts remain unclear. This… read more here.
Keywords: graves orbital; orbital fibroblasts; growth factor; induced myofibroblast ... See more keywords