P06 A novel drug combination produces a synergistic effect when inhibiting myofibroblast transformation in an in vitro model of hypertrophic scarring
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljae105.028
Abstract: Hypertrophic scars affect 91% of patients with burns and yet, there is currently no effective treatment for their prevention. Myofibroblasts are key cells in the pathogenesis of hypertrophic scars, with the inhibition of myofibroblast transformation… read more here.
Keywords: drug; myofibroblast transformation; drug class; effect ... See more keywords
miR‐21 promotes cardiac fibroblast‐to‐myofibroblast transformation and myocardial fibrosis by targeting Jagged1
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DOI: 10.1111/jcmm.13654
Abstract: Myocardial fibrosis after myocardial infarction (MI) is a leading cause of heart diseases. MI activates cardiac fibroblasts (CFs) and promotes CF to myofibroblast transformation (CMT). This study aimed to investigate the role of miR‐21 in… read more here.
Keywords: mir; jagged1; myocardial fibrosis; myofibroblast transformation ... See more keywords
Upregulation of C/EBP Homologous Protein induced by ER Stress Mediates Epithelial to Myofibroblast Transformation in ADTKD-UMOD
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DOI: 10.7150/ijms.65036
Abstract: Autosomal dominant tubulointerstitial kidney disease due to UMOD mutations (ADTKD-UMOD) results in chronic interstitial nephritis, which gradually develops into end-stage renal disease. It is believed that the accumulation of mutant uromodulin causes the endoplasmic reticulum… read more here.
Keywords: epithelial myofibroblast; chop; expression; myofibroblast transformation ... See more keywords