Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma (Adv. Sci. 1/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470006
Abstract: Macrophage–Myofibroblast Transition In article number 2302203, Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Patrick Ming‐Kuen Tang, and co‐workers, elucidated dynamics of cancer‐associated fibroblast (CAF) with integrative bioinformatics at single‐cell resolution, therefore unexpectedly identified the importance of… read more here.
Keywords: myofibroblast transition; cell; macrophage myofibroblast; lung ... See more keywords
UUO induces lung fibrosis with macrophage-myofibroblast transition in rats.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107396
Abstract: Progression of chronic kidney disease (CKD) to uremia is often accompanied by varying degrees of lung damage and this is also an important cause of death. Although there are many studies on the mechanism of… read more here.
Keywords: myofibroblast transition; lung fibrosis; macrophage myofibroblast; fibrosis ... See more keywords
ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46357-x
Abstract: Cardiac macrophage contributes to the development of cardiac fibrosis, but factors that regulate cardiac macrophages transition and activation during this process remains elusive. Here we show, by single-cell transcriptomics, lineage tracing and parabiosis, that cardiac… read more here.
Keywords: myofibroblast transition; macrophage myofibroblast; fibrosis; cardiac fibrosis ... See more keywords
Fibroblast to myofibroblast transition is enhanced by increased cell density
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-08-0536
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic disease of the lung caused by a rampant inflammatory response that results in the deposition of excessive extracellular matrix (ECM). IPF patient lungs also develop fibroblastic foci that… read more here.
Keywords: increased cell; myofibroblast transition; density; cell density ... See more keywords
Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Gut"
DOI: 10.1136/gutjnl-2023-329671
Abstract: Objective Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins.… read more here.
Keywords: myofibroblast transition; fibrosis; suv39h1; liver fibrosis ... See more keywords
Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.681061
Abstract: Objective Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a… read more here.
Keywords: protein; systemic sclerosis; gremlin; myofibroblast transition ... See more keywords
The role of the macrophage-to-myofibroblast transition in renal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.934377
Abstract: Renal fibrosis causes structural and functional impairment of the kidney, which is a dominant component of chronic kidney disease. Recently, a novel mechanism, macrophage-to-myofibroblast transition (MMT), has been identified as a crucial component in renal… read more here.
Keywords: renal fibrosis; fibrosis; macrophage myofibroblast; myofibroblast transition ... See more keywords