Crystallinity of hydroxyapatite drives myofibroblastic activation and calcification in aortic valves.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.02.024
Abstract: Calcific aortic valve disease (CAVD) is an inexorably degenerative pathology characterized by progressive calcific lesion formation on the valve leaflets. The interaction of valvular cells in advanced lesion environments is not well understood yet highly… read more here.
Keywords: crystallinity; myofibroblastic activation; calcification; endothelial cells ... See more keywords
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000493217
Abstract: Myofibroblasts are central mediators of fibrosis. Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally defined by acquired contractile function and high synthetic ability to produce extracellular matrix (ECM).… read more here.
Keywords: myofibroblastic activation; signaling mechanisms; inside signaling; activation ... See more keywords
Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020457
Abstract: Rationale—Calcific aortic valve stenosis (CAVS) is a pathological condition of the aortic valve with a prevalence of 3% in the general population. It is characterized by massive rearrangement of the extracellular matrix, mostly due to… read more here.
Keywords: aortic valve; calcification; calcification myofibroblastic; valve interstitial ... See more keywords