Molecular Effects of Cardiac Troponin DCM Mutations on Calcium Sensitivity and Myofilament Activation - an Integrated Multi-Scale Modeling Study
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1744
Abstract: Mutations in cTnC (D75Y, E59D and G159D), a key regulatory protein of myofilament contraction, have been associated with dilated cardiomyopathy (DCM). Despite reports of altered myofilament function in these mutants, the underlying molecular alterations caused… read more here.
Keywords: ctnc; calcium sensitivity; molecular effects; multi scale ... See more keywords
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221244120
Abstract: Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is located in the cTnT N-terminal (TnT1) loop region and is known for… read more here.
Keywords: ctnt i79n; myofilament; cardiac troponin; relaxed state ... See more keywords