Nanomechanical Phenotypes in Hypertrophic Cardiomyopathy caused by Missense Mutations in Cardiac Myosin-Binding Protein C
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.907
Abstract: We investigate the molecular mechanisms that induce hypertrophic cardiomyopathy (HCM) in the 10-20% of patients who carry missense mutations in MYBPC3, the gene coding for cardiac myosin-binding protein C (cMyBP-C). Our starting point is the… read more here.
Keywords: protein; myosin binding; hypertrophic cardiomyopathy; missense mutations ... See more keywords
Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.05.001
Abstract: Cardiac myosin binding protein-C (cMyBP-C) is an essential regulatory protein required for proper systolic contraction and diastolic relaxation. We previously showed that N'-terminal domains of cMyBP-C stimulate contraction by binding to actin and activating the… read more here.
Keywords: myosin binding; relaxation; binding protein; binding actin ... See more keywords
DIASTOLIC FUNCTION IN MYOSIN-BINDING PROTEIN C FOUNDER MUTATION CARRIERS WITH AND WITHOUT CLINICAL EVIDENCE OF HYPERTROPHIC CARDIOMYOPATHY
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)31538-4
Abstract: The MYBPC3 (Myosin-binding protein C) c.927-2A>G founder mutation accounts for >90% of sarcomeric hypertrophic cardiomyopathy (HCM) in Iceland, allowing unique opportunity to explore the relation between genotype and clinical phenotype. This study explores the burden… read more here.
Keywords: myosin binding; hypertrophic cardiomyopathy; binding protein; founder mutation ... See more keywords
Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner
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DOI: 10.1038/s41598-018-21053-1
Abstract: Muscle contraction, which is initiated by Ca2+, results in precise sliding of myosin-based thick and actin-based thin filament contractile proteins. The interactions between myosin and actin are finely tuned by three isoforms of myosin binding… read more here.
Keywords: myosin binding; muscle; thin filament; binding protein ... See more keywords
High myosin binding protein H expression predicts poor prognosis in glioma patients
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DOI: 10.1038/s41598-022-05512-4
Abstract: Glioma is the most common and fatal primary brain tumor in humans. Myosin binding protein H (MYBPH), which was first identified as an important myofibrillar constituent of vertebrate skeletal and cardiac muscles, reduces cell motility… read more here.
Keywords: tumor; glioma patients; expression; binding protein ... See more keywords
Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1816480116
Abstract: Significance Diverse demands on cardiac muscle require the fine-tuning of contraction. Cardiac myosin binding protein-C (cMyBP-C) is involved in this regulation; however, its precise molecular mechanism of action remains uncertain. By imaging the interactions of… read more here.
Keywords: calcium; thin filament; myosin binding; mechanism ... See more keywords
Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1903033116
Abstract: Significance Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a key regulator of myocardial contractility, and dephosphorylation of cMyBP-C is associated with heart failure. However, the molecular mechanisms underlying contractile regulation by cMyBP-C phosphorylation are… read more here.
Keywords: phosphorylation; myosin binding; binding protein; cmybp ... See more keywords
Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers
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DOI: 10.1136/openhrt-2019-001220
Abstract: Objective The myosin-binding protein C (MYBPC3) c.927-2A>G founder mutation accounts for >90% of sarcomeric hypertrophic cardiomyopathy (HCM) in Iceland. This cross-sectional observational study explored the penetrance and phenotypic burden among carriers of this single, prevalent… read more here.
Keywords: myosin binding; age; founder mutation; binding protein ... See more keywords
Prevalence of cardiac myosin-binding protein C3 mutations in Maine Coon cats with hypertrophic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary World"
DOI: 10.14202/vetworld.2022.502-508
Abstract: Background and Aim: Hypertrophic cardiomyopathy (HCM) is a common heart problem that affects many cats. Although cats with HCM are symptomatic, some die suddenly or develop congestive heart failure. Therefore, this study aimed to estimate… read more here.
Keywords: maine coon; prevalence; coon cats; myosin binding ... See more keywords
Cryo-electron microscopy reveals cardiac myosin binding protein-C M-domain interactions with the thin filament.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.2139/ssrn.4198996
Abstract: Cardiac myosin binding protein C (cMyBP-C) modulates cardiac contraction via direct interactions with cardiac thick (myosin) and thin (actin) filaments (cTFs). While its C-terminal domains (e.g. C8-C10) anchor cMyBP-C to the backbone of the thick… read more here.
Keywords: cardiac myosin; microscopy; domain; myosin ... See more keywords
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168840
Abstract: Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate the c-MYBPC3 HCM-related cardiac impairment,… read more here.
Keywords: binding protein; hypertrophic cardiomyopathy; cardiac myosin; heart ... See more keywords